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1. (WO2004009543) 1-CARBONYL-4-CYANO-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009543    International Application No.:    PCT/EP2003/008138
Publication Date: 29.01.2004 International Filing Date: 18.07.2003
Chapter 2 Demand Filed:    09.02.2004    
IPC:
A61K 31/427 (2006.01), A61K 31/4402 (2006.01), C07D 401/04 (2006.01), C07D 409/04 (2006.01), C07D 417/04 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB) (For All Designated States Except US).
BURTON, George [GB/US]; (US) (For US Only).
GOODLAND, Helen, Susanne [GB/GB]; (GB) (For US Only).
HAIGH, David [GB/GB]; (GB) (For US Only).
KIESOW, Terence, John [US/US]; (US) (For US Only).
KU, Thomas, W. [US/US]; (US) (For US Only).
SLATER, Martin, John [GB/GB]; (GB) (For US Only)
Inventors: BURTON, George; (US).
GOODLAND, Helen, Susanne; (GB).
HAIGH, David; (GB).
KIESOW, Terence, John; (US).
KU, Thomas, W.; (US).
SLATER, Martin, John; (GB)
Agent: GIDDINGS, Peter, John; GlaxoSmithKline, CIP (CN925.1), 980 Great West Road, Brentford, Middlesex TW8 9GS (GB)
Priority Data:
0216985.2 22.07.2002 GB
Title (EN) 1-CARBONYL-4-CYANO-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS
(FR) COMPOSES
Abstract: front page image
(EN)Novel anti-viral agents of Formula (I) wherein: A represents OH; B represents C(O)R1 wherein R1 is selected from the group consisting of C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents hydrogen or C1-6alkyl; E represents hydrogen, C1-6alkyl, aryl or heteroaryl; and F represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.
(FR)L'invention concerne des agents antiviraux de formule (I), y compris leurs sels, solvats et esters. Dans cette formule, A est OH; B est C(O)R1 et R1 appartient au groupe qui comprend alkyle C1-6, aryle, hétéroaryle, arylalkyle, et hétéroarylalkyle; C est alkyle C1-6, aryle, hétéroaryle ou hétérocyclyle; D est hydrogène ou alkyle C1-6; E est hydrogène, alkyle C1-6, aryle ou hétéroaryle; et F est hydrogène, alkyle C1-6, hétérocyclylalkyle, arylalkyle ou hétéroarylalkyle. L'invention concerne également des procédés d'élaboration et d'utilisation (traitement du VHC) correspondants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)