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1. WO2004009098 - ANTISENSE COMPOUNDS, METHODS AND COMPOSITIONS FOR TREATING MMP-12 RELATED INFLAMMATORY DISORDERS

Publication Number WO/2004/009098
Publication Date 29.01.2004
International Application No. PCT/SE2003/001223
International Filing Date 17.07.2003
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • INDEX PHARMACEUTICALS AB [SE]/[SE] (AllExceptUS)
  • DIECKMANN, Andreas [DE]/[SE] (UsOnly)
  • LÖFBERG, Robert [SE]/[SE] (UsOnly)
  • VON STEIN, Oliver [GB]/[SE] (UsOnly)
  • VON STEIN, Petra [DE]/[SE] (UsOnly)
  • GOOD, Liam [CA]/[SE] (UsOnly)
Inventors
  • DIECKMANN, Andreas
  • LÖFBERG, Robert
  • VON STEIN, Oliver
  • VON STEIN, Petra
  • GOOD, Liam
Agents
  • HOLMBERG, Martin
Priority Data
0202253-118.07.2002SE
60/407,68004.09.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTISENSE COMPOUNDS, METHODS AND COMPOSITIONS FOR TREATING MMP-12 RELATED INFLAMMATORY DISORDERS
(FR) COMPOSES ANTISENS, PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES LIES A LA METALLOPROTEINASE MATRICIELLE-12 (MMP-12)
Abstract
(EN)
The present invention relates to antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding mammalian MMP-12. More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding MMP-12 and thereby inhibiting the expression of the MMP-12 protein product, as well as pharmaceutical compositions thereof and methods of its use. The antisense oligonecleotide compounds are used for treating diseases such as inflammatory bowel disease, rheumatoid arthritis, psoriasis, emphysema and asthma.
(FR)
La présente invention a trait à des composés d'oligonucléotides antisens destinés à être utilisés dans la modulation de la fonction de molécules d'acide nucléique codant pour la métalloprotéinase matricielle-12 (MMP-12). De manière plus spécifique, l'invention a trait à des composés présentant une longueur de 8 à 50 nucléobases capables d'hybridation spécifique avec des molécules d'acide nucléique codant pour le MMP-12, permettant ainsi l'inhibition du produit de la protéine de la MMP-12, ainsi que des compositions pharmaceutiques en contenant et son procédé d'utilisation. Les composés d'oligonucléotides antisens sont utilisés pour le traitement de maladies telles que la maladie intestinale inflammatoire, la polyarthrite rhumatoïde, le psoriasis, l'emphysème et l'asthme.
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