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1. (WO2004009057) PROCESS FOR THE PREPARATION OF CRYSTALLINE NANO-PARTICLE DISPERSIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/009057    International Application No.:    PCT/GB2003/003044
Publication Date: 29.01.2004 International Filing Date: 14.07.2003
Chapter 2 Demand Filed:    20.01.2004    
IPC:
A61K 9/51 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; Sodertalje, S-151 85 (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1K 1LN (GB) (MG only).
SKANTZE, Tommy, Urban [SE/SE]; (SE) (For US Only).
LINDFORS, Per, Lennart [SE/SE]; (SE) (For US Only).
FORSSEN, Sara [SE/SE]; (SE) (For US Only)
Inventors: SKANTZE, Tommy, Urban; (SE).
LINDFORS, Per, Lennart; (SE).
FORSSEN, Sara; (SE)
Agent: ASTRAZENECA; Global Intellectual Property, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG (GB)
Priority Data:
0216700.5 18.07.2002 GB
Title (EN) PROCESS FOR THE PREPARATION OF CRYSTALLINE NANO-PARTICLE DISPERSIONS
(FR) PROCEDE DE PREPARATION DE DISPERSIONS DE NANOPARTICULES CRISTALLINES
Abstract: front page image
(EN)A process for the preparation of a dispersion of crystalline nano-particles in an aqueous medium comprising combining (i) a first solution comprising a substantially water-insoluble substance in a water-miscible organic solvent with; (ii) an aqueous phase comprising water and optionally a stabiliser, to form a dispersion of amorphous particles; and (iii) sonicating the dispersion of amorphous particles for a sufficient period to form crystalline nano-particles of the substantially water-insoluble substance. The process provides nano-crystals with a mean hydrodynamic diameter of less than 1 micron, particularly less than 300 nm and is particularly useful for the preparation of nano-crystalline dispersions of pharmaceutical substances.
(FR)L'invention a trait à un procédé de préparation d'une dispersion de nanoparticules cristallines dans un milieu aqueux. Ledit procédé consiste : à combiner (i) une première solution contenant une substance sensiblement insoluble dans l'eau dans un solvant organique miscible dans l'eau, avec (ii) une phase aqueuse contenant de l'eau et éventuellement un stabilisant, afin de former une dispersion de particules amorphes ; et (iii) à procéder à la sonification de la dispersion de particules amorphes, pendant un temps suffisant pour que se forment des nanoparticules cristallines de la substance sensiblement insoluble dans l'eau. Le procédé permet d'obtenir des nanocristaux présentant un diamètre hydrodynamique moyen inférieur à 1 micron, en particulier inférieur à 300 nm. Ledit procédé est notamment utile à la préparation de dispersions nanocristallines de substances pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)