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1. (WO2004007754) MODULATORS OF CELLULAR PROLIFERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007754    International Application No.:    PCT/US2003/022164
Publication Date: 22.01.2004 International Filing Date: 14.07.2003
IPC:
G01N 33/50 (2006.01)
Applicants: RIGEL PHARMACEUTICALS, INC. [US/US]; 1180 Veterans Blvd., South San Francisco, CA 94080 (US) (For All Designated States Except US).
HITOSHI, Yasumichi [JP/US]; (US) (For US Only).
JENKINS, Yonchu [US/US]; (US) (For US Only).
MARKOVTSOV, Vadim [BY/US]; (US) (For US Only)
Inventors: HITOSHI, Yasumichi; (US).
JENKINS, Yonchu; (US).
MARKOVTSOV, Vadim; (US)
Agent: KELLY, Beth, L.; Townsend and Townsend and Crew LLP, Two Embarcadero Center, 8th Floor, San Francisco, CA 94111-3834 (US)
Priority Data:
60/395,443 12.07.2002 US
Title (EN) MODULATORS OF CELLULAR PROLIFERATION
(FR) MODULATEURS DE LA PROLIFERATION CELLULAIRE
Abstract: front page image
(EN)The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding protein kinase C &zgr; (PKC-&zgr;), phospholipase C-&bgr;1 (PLC-ß1), protein tyrosine kinase 2 (FAK), protein tyrosine kinase 2b (FAK2), casein kinase 2 (CK2), cMET tyrosine kinase (cMET), flap structure specific endonuclease 1 (FEN1), REV1 dCMP transferase (REV1), apurinic/apyrimidinic nuclease 1 (APE1), cyclin dependent kinase 3 (CDK3), PIM1 kinase (PIM1), cell division cycle 7 kinase (CDC7L1), cyclin dependent kinase 7 (CDK7), cytokine inducible kinase (CNK), potentially prenylated protein tyrosine phosphatase (PRL-3), serine threonine kinase 2 (STK2) or (NEK4), cyclin dependent serine threonine kinase (NKIAMRE), or histone acetylase (HBO1), which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of protein kinase C &zgr; (PKC-&zgr;), phospholipase C-ß1 (PLC-ß1), protein tyrosine kinase 2 (FAK), protein tyrosine kinase 2b (FAK2), casein kinase 2 (CK2), cMET tyrosine kinase (cMET), flap structure specific endonuclease 1 (FEN1), REV1 dCMP transferase (REV1), apurinic/apyrimidinic nuclease 1 (APE1), cyclin dependent kinase 3 (CDK3), PIM1 kinase (PIM1), cell division cycle 7 kinase (CDC7L1), cyclin dependent kinase 7 (CDK7), cytokine inducible kinase (CNK), potentially prenylated protein tyrosine phosphatase (PRL-3), serine threonine kinase 2 (STK2) or (NEK4), cyclin dependent serine threonine kinase (NKIAMRE), or histone acetylase (HBO1), as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.
(FR)la présente invention concerne la régulation de la prolifération cellulaire. Cette invention concerne plus particulièrement des acides nucléiques codant pour les enzymes suivantes: protéine kinase C ? (PKC-?), phospholipase C-?1 (PLC-ß1), protéine tyrosine kinase 2 (FAK), protéine tyrosine kinase 2b (FAK2), caséine kinase 2 (CK2), cMET tyrosine kinase (cMET), endonucléase 1 spécifique à structure en volet (FEN1), transférase REV1 dCMP (REV1), nucléase 1 apurinique/apyrimidinique (APE1), kinase 3 dépendant de la cycline (CDK3), PIM1 kinase (PIM1), kinase 7 du cycle de division cellulaire (CDC7L1), kinase 7 dépendant de la cycline (CDK7), kinase inductible par la cytokine (CNK), protéine tyrosine phosphatase potentiellement prénylatée (PRL-3), sérine thréonine kinase 2 (STK2) ou (NEK4), serine threonine kinase dépendant de la cycline (NKIAMRE), ou histone acétylase (HBO1), qui sont impliquées dans la modulation de l'arrêt du cycle cellulaire. L'invention concerne en outre des méthodes d'identification et d'utilisation d'agents, dont des compositions chimiques à petites molécules, anticorps, peptides, peptides cycliques, acides nucléiques, ARNi, acides nucléiques antisens et ribozymes qui modulent l'arrêt du cycle cellulaire via la modulation de la protéine kinase C ? (PKC-?), phospholipase C-ß1 (PLC-ß1), protéine tyrosine kinase 2 (FAK), protéine tyrosine kinase 2b (FAK2), caséine kinase 2 (CK2), cMET tyrosine kinase (cMET), endonucléase spécifique 1 à structure en volet (FEN1), REV1 dCMP transférase (REV1), nucléase 1 apurinique/apyrimidinique (APE1), kinase 3 dépendante de la cycline (CDK3), PIM1 kinase (PIM1), kinase 7 du cycle de division cellulaire (CDC7L1), protéine tyrosine phosphatase potentiellement prénylatée (PRL-3), sérine thréonine kinase 2 (STK2) ou (NEK4), serine thréonine kinase dépendant de la cycline (NKIAMRE), ou histone acétylase (HBO1), ainsi que l'utilisation de profiles d'expression et de compositions pour le diagnostic et la thérapie en rapport avec la régulation du cycle cellulaire et la modulation de la prolifération cellulaire, <i>c'est à dire pour le traitement du cancer et autres pathologies liées à la prolifération cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)