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1. (WO2004007746) METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IgE SYNTHESIS UTILIZING A B-CELL ASSOCIATED PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007746    International Application No.:    PCT/US2003/021704
Publication Date: 22.01.2004 International Filing Date: 10.07.2003
Chapter 2 Demand Filed:    12.02.2004    
IPC:
G01N 33/566 (2006.01), C07K 4/00 (2006.01)
Applicants: RIGEL PHARMACEUTICALS, INC. [US/US]; 1180 Veterans Blvd., South San Francisco, CA 94080 (US) (For All Designated States Except US).
MASUDA, Esteban [CO/US]; (US) (For US Only).
KINSELLA, Todd, M. [US/US]; (US) (For US Only).
WARNER, Justin, E. [US/US]; (US) (For US Only).
KINOSHITA, Taisei [JP/US]; (US) (For US Only).
BENNETT, Mark, K. [US/US]; (US) (For US Only).
ANDERSON, David, C. [US/US]; (US) (For US Only)
Inventors: MASUDA, Esteban; (US).
KINSELLA, Todd, M.; (US).
WARNER, Justin, E.; (US).
KINOSHITA, Taisei; (US).
BENNETT, Mark, K.; (US).
ANDERSON, David, C.; (US)
Agent: PEASE, Ann; Dorsey & Whitney LLP, 4 Embarcadero Center, Suite 3400, San Francisco, CA 94111 (US)
Priority Data:
10/197,919 16.07.2002 US
Title (EN) METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IgE SYNTHESIS UTILIZING A B-CELL ASSOCIATED PROTEIN
(FR) PROCEDES D'IDENTIFICATION DE COMPOSES MODULANT LA SYNTHESE DES IGE A MEDIATION ASSUREE PAR LES RECEPTEURS DE L'IL-4 AU MOYEN D'UNE PROTEINE ASSOCIEE AUX CELLULES B
Abstract: front page image
(EN)The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
(FR)La présente invention se rapporte à des composés pouvant moduler la production des IgE à médiation assurée par des récepteurs de l'IL-4, ainsi qu'à des processus induits par l'IL-4 qui lui sont associés, à des procédés et à des kits d'identification de ces composés qui utilisent une BAP-37 en tant qu'analyte de substitution ainsi qu'à des procédés d'utilisation de ces composés dans une variété de contextes in vitro, in vitro et ex vivo.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)