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Machine translation
1. (WO2004007721) CONJUGATE FOR DOUBLE-STRANDED RNA SEQUENCE RELEASING AND METHODS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007721    International Application No.:    PCT/IB2003/002828
Publication Date: 22.01.2004 International Filing Date: 17.07.2003
Chapter 2 Demand Filed:    16.02.2004    
IPC:
A61K 38/00 (2006.01), A61K 47/48 (2006.01), C12N 15/11 (2006.01)
Applicants: UNIVERSITY OF OTAGO [NZ/NZ]; P.O. BOX 56, Dunedin (NZ) (For All Designated States Except US).
ECCLES, Roger, Michael [NZ/NZ]; (NZ) (For US Only).
MURATOVSKA, Alexandra [NZ/NZ]; (NZ) (For US Only)
Inventors: ECCLES, Roger, Michael; (NZ).
MURATOVSKA, Alexandra; (NZ)
Agent: ADAMS, Matthew D; A J Park, 6th Floor Huddart Parker Building, Post Office Square, PO Box 949, 6015 Wellington (NZ)
Priority Data:
60/396,093 17.07.2002 US
Title (EN) CONJUGATE FOR DOUBLE-STRANDED RNA SEQUENCE RELEASING AND METHODS THEREOF
(FR) CONJUGUE DE LIBERATION DE SEQUENCES D'ARN DOUBLE BRIN ET METHODES ASSOCIEES
Abstract: front page image
(EN)The present invention relates to a conjugate having the following formula: X-Y-Z, wherein X is a double-stranded RNA, preferably short interfering RNA sequence (siRNA); Y is a bound or a binding molecule covalently linking X and Z together; and Z is a membrane permeant peptide. The present invention also relates to a method for releasing double-stranded RNA into cytoplasm of a cell comprising the step of administering to the cell an effective amount of the conjugate of the present invention to the cell, wherein the double-stranded RNA is released from the membrane permeant peptide into the cytoplasm.
(FR)L'invention porte sur un conjugué de formule: X-Y-Z, dans laquelle: X est un ARN double brin, de préférence une séquence d'ARN court interférant (siRNA); Y est une liaison ou une molécule de liaison liant X à Y par covalence; et Z est un peptide membranaire perméant. L'invention porte également sur un procédé de libération d'ARN double brin dans le cytoplasme d'une cellule consistant à administrer à la cellule une dose efficace dudit conjugué pour provoquer la libération de l'ARN double brin du peptide membranaire perméant dans le cytoplasme.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)