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1. (WO2004007717) PROTEOMIC SCREEN TO IDENTIFY DISEASE-RELATED BIOLOGICAL MOLECULES AND INHIBITORS THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007717    International Application No.:    PCT/EP2003/007660
Publication Date: 22.01.2004 International Filing Date: 15.07.2003
Chapter 2 Demand Filed:    14.02.2004    
IPC:
C07K 16/28 (2006.01), C12N 15/10 (2006.01)
Applicants: XERION PHARMACEUTICALS AG [DE/DE]; Sauerbruchstr. 50, 81377 München (DE) (For All Designated States Except US).
UNGER, Christine, Margarete [DE/DE]; (DE) (For US Only).
BESTE, Gerald [DE/DE]; (DE) (For US Only).
JENSEN, Kristian, H. [DK/DE]; (DE) (For US Only).
ZEHETMEIER, Carolin [DE/DE]; (DE) (For US Only).
KNAUER, Roland [DE/DE]; (DE) (For US Only).
GUELBENZU, Blanca, Lain [ES/US]; (US) (For US Only).
TORELLA, Claudia [IT/DE]; (DE) (For US Only).
ILAG, L., Leodevico [PH/DE]; (DE) (For US Only)
Inventors: UNGER, Christine, Margarete; (DE).
BESTE, Gerald; (DE).
JENSEN, Kristian, H.; (DE).
ZEHETMEIER, Carolin; (DE).
KNAUER, Roland; (DE).
GUELBENZU, Blanca, Lain; (US).
TORELLA, Claudia; (DE).
ILAG, L., Leodevico; (DE)
Agent: FLEUCHAUS, Andrea; c/o Fleuchaus & Gallo, Melchiorstr. 42, 81479 München (DE)
Priority Data:
02015591.7 15.07.2002 EP
60/410,331 11.09.2002 US
Title (EN) PROTEOMIC SCREEN TO IDENTIFY DISEASE-RELATED BIOLOGICAL MOLECULES AND INHIBITORS THERETO
(FR) CRIBLAGE PROTEOMIQUE POUR IDENTIFIER DES MOLECULES BIOLOGIQUES ASSOCIEES A DES MALADIES ET LEURS INHIBITEURS
Abstract: front page image
(EN)The invention provides a new paradigm for a screening method by combining the biochemical approach of specific binding between a ligand and a target, e.g. an antibody and an antigen, with the genetic principle of a functional screen. The present invention demonstrates its utility for identifying novel disease-relevant proteins and inhibitory ligands, e.g. antibodies or antibody fragments, that may serve as therapeutic leads for a wide variety of diseases, whether the cause of the disease is derivable from a virus, a bacterium, a lower eukaryote or from a misregulation of the cells of the subject to be treated.
(FR)L'invention concerne un nouveau paradigme pour un procédé de criblage par combinaison d'une approche biochimique de liaison spécifique entre un ligand et une cible, par exemple un anticorps et un antigène, au moyen d'un principe génétique d'un criblage fonctionnel. L'objectif de l'invention est d'identifier des protéines associées à de nouvelles maladies et des ligands inhibiteurs, par exemple des anticorps ou des fragments d'anticorps, qui peuvent servir en tant qu'agents thérapeutiques pour une pluralité de maladies, la cause de la maladie étant dérivée d'un virus, d'une bactérie, d'un eucaryote inférieur ou d'un dérèglement de cellules chez le sujet à traiter.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)