Processing

Please wait...

Settings

Settings

Goto Application

1. WO2004007707 - PROCESS FOR PRODUCING A VIRUS-INACTIVATED THROMBIN PREPARATION

Publication Number WO/2004/007707
Publication Date 22.01.2004
International Application No. PCT/GB2003/002942
International Filing Date 07.07.2003
Chapter 2 Demand Filed 28.01.2004
IPC
A61L 2/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
C12N 9/74 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
74Thrombin
CPC
A61L 2/0088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
0005for pharmaceuticals, biologicals or living parts
0082using chemical substances
0088Liquid substances
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
C12N 9/6429
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6424Serine endopeptidases (3.4.21)
6429Thrombin (3.4.21.5)
C12Y 304/21005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
21Serine endopeptidases (3.4.21)
21005Thrombin (3.4.21.5)
Applicants
  • NATIONAL BLOOD AUTHORITY [GB]/[GB] (AllExceptUS)
  • CONNOLLY, Caroline [GB]/[GB] (UsOnly)
  • HARDWAY, Christopher [GB]/[GB] (UsOnly)
  • EVANS, David [GB]/[GB] (UsOnly)
  • FELDMAN, Peter [GB]/[GB] (UsOnly)
Inventors
  • CONNOLLY, Caroline
  • HARDWAY, Christopher
  • EVANS, David
  • FELDMAN, Peter
Agents
  • FRANK, B., Dehn & Co.
Priority Data
0216002.610.07.2002GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCING A VIRUS-INACTIVATED THROMBIN PREPARATION
(FR) FABRICATION D'UNE PREPARATION DE THROMBINE A VIRUS INACTIVE
Abstract
(EN)
A method for the preparation of virus-inactivated thrombin comprising solvent-detergent virus inactivation of a solution comprising prothrombin and factor X, loading the virus inactivated prothrombin and factor X onto an anion exchange medium, washing the medium to remove the reagents used for the solvent-detergent virus inactivation, and activating the prothrombin on the medium to form thrombin by the addition of metal ions, preferably calcium ions. The thrombin is then preferably selectively eluted from the anion exchange medium.
(FR)
Cette invention concerne une méthode de préparation d'une thrombine à virus inactivé. Cette méthode consiste à : inactiver un virus par solvant-détergent dans une solution comprenant une prothrombine et un facteur X; charger la prothrombine à virus inactivé et le facteur X sur un support d'échange anionique; laver le support pour faire disparaître les réactifs utilisés lors de l'inactivation du virus par solvant-détergent; et activer la prothrombine sur ce support pour former une thrombine par adjonction d'ions métal, de préférence d'ions calcium. Ensuite, il est préférable d'éluer sélectivement la thrombine à partir du support d'échange anionique.
Also published as
CO05007426
CRCR2005-007662
NO20050090
NZ537502
PL374747
PLP.374747
Other related publications
Latest bibliographic data on file with the International Bureau