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1. (WO2004007557) TF ANTAGONIST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007557    International Application No.:    PCT/DK2003/000480
Publication Date: 22.01.2004 International Filing Date: 09.07.2003
Chapter 2 Demand Filed:    05.02.2004    
A61K 38/00 (2006.01), A61K 47/48 (2006.01), A61K 51/08 (2006.01), C07K 5/06 (2006.01), C07K 14/705 (2006.01), C07K 14/745 (2006.01)
Applicants: NOVO NORDISK A/S [DK/DK]; Novo Allé, DK-2880 Bagsværd (DK)
Inventors: STENNICKE, Henning, Ralf; (DK).
PETERSEN, Lars, Christian; (DK).
BJØRN, Søren, E.; (DK)
Priority Data:
PA 2002 01100 12.07.2002 DK
Abstract: front page image
(EN)This invention relates to conjugates of tissue factor (TF) antagonists and a domain that act to elicit a cytotoxic response. The conjugate bind TF with high affinity and specificity but do not initiate blood coagulation. In one embodiment of the present invention the TF antagonist is FVIIa polypeptides chemically inactivated in the active site. In another embodiment the TF antagonist is an antibody against TF. The invention also relates to pharmaceutical compositions comprising the conjugates as well as their use in the prophylaxis or treatment of diseases or disorders related to patho-physiological TF functions including cancer, inflammation, atherosclerosis and ischemia/reperfusion.
(FR)L'invention concerne des nouveaux composés qui se lient au facteur tissulaire et participent indirectement à une réponse cytotoxique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)