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Machine translation
1. (WO2004007550) MCAM INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007550    International Application No.:    PCT/EP2003/007661
Publication Date: 22.01.2004 International Filing Date: 15.07.2003
Chapter 2 Demand Filed:    14.02.2004    
IPC:
C07K 16/28 (2006.01), C12N 15/10 (2006.01)
Applicants: XERION PHARMACEUTICALS AG [DE/DE]; Sauerbruchstr. 50, 81377 München (DE) (For All Designated States Except US).
UNGER, Christine, Margarete [DE/DE]; (DE) (For US Only).
ZEHETMEIER, Carolin [DE/DE]; (DE) (For US Only).
TORELLA, Claudia [IT/DE]; (DE) (For US Only).
NIEWÖHNER, Jens [DE/DE]; (DE) (For US Only).
AHRENS, Bianca [DE/DE]; (DE) (For US Only).
BESTE, Gerald [DE/DE]; (DE) (For US Only)
Inventors: UNGER, Christine, Margarete; (DE).
ZEHETMEIER, Carolin; (DE).
TORELLA, Claudia; (DE).
NIEWÖHNER, Jens; (DE).
AHRENS, Bianca; (DE).
BESTE, Gerald; (DE)
Agent: FLEUCHAUS, Andrea; c/o Fleuchaus & Gallo, Melchiorstr. 42, 81479 München (DE)
Priority Data:
02015591.7 15.07.2002 EP
60/410,331 11.09.2002 US
Title (EN) MCAM INHIBITORS
(FR) INHIBITEURS DE MCAM
Abstract: front page image
(EN)The present invention relates to polypeptides inhibiting the function of MCAM in naturally occurring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of cancers, particularly for reducing the invasiveness, proliferation, adhesion and/or the metastatic potential of specific cancer cells. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional MCAM for its invasiveness, adhesiveness, proliferation and/or its metastatic potential. Finally, a method is provided that allows identifying an antibody or an antibody fragment capable of inhibiting invasiveness, proliferation or adhesiveness of tumor cells.
(FR)La présente invention concerne des polypeptides inhibant la fonction de la molécule MCAM dans des cellules tumorales d'origine naturelle ainsi que leur utilisation. Cette invention concerne également l'utilisation d'autres molécules inhibant la fonction de la MCAM dans le traitement de cancers, notamment afin de réduire le pouvoir envahissant, la prolifération, l'adhésion et/ou le potentiel métastatique de cellules cancéreuses spécifiques. Ladite invention concerne en outre une méthode permettant de déterminer si le pouvoir envahissant, l'adhésivité, la prolifération et/ou le potentiel métastatique d'une cellule tumorale d'origine naturelle dépendent de MCAM fonctionnelles ainsi qu'une méthode permettant d'identifier un anticorps ou un fragment d'anticorps capable d'inhiber le pouvoir envahissant, la prolifération ou l'adhésivité de cellules tumorales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)