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Machine translation
1. (WO2004007536) INTERACTIONS OF THE EPSTEIN-BARR VIRUS PROTEIN EBNA1, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007536    International Application No.:    PCT/CA2003/001019
Publication Date: 22.01.2004 International Filing Date: 16.07.2003
IPC:
A61K 38/00 (2006.01), C07K 14/05 (2006.01), C12N 15/62 (2006.01)
Applicants: AFFINIUM PHARMACEUTICALS, INC. [CA/CA]; 100 University Avenue, 10th Floor, South Tower, Toronto, Ontario M5J 1V6 (CA) (For All Designated States Except US).
FRAPPIER, Lori [CA/CA]; (CA) (For US Only).
HOLOWATY, Melissa [CA/CA]; (CA) (For US Only).
GREENBLATT, Jack [CA/CA]; (CA) (For US Only).
ZEGHOUF, Mahel [FR/FR]; (FR) (For US Only)
Inventors: FRAPPIER, Lori; (CA).
HOLOWATY, Melissa; (CA).
GREENBLATT, Jack; (CA).
ZEGHOUF, Mahel; (FR)
Agent: BERESKIN & PARR; 40 King Street West, 40th Floor, Toronto, Ontario M5H 3Y2 (CA)
Priority Data:
60/396,118 16.07.2002 US
Title (EN) INTERACTIONS OF THE EPSTEIN-BARR VIRUS PROTEIN EBNA1, AND USES THEREOF
(FR) NOUVELLES INTERACTIONS DE LA PROTEINE DU VIRUS D'EPSTEIN-BARR EBNA1, COMPOSITIONS ET METHODES ASSOCIEES
Abstract: front page image
(EN)The invention provides complexes of EBNA1 and at least one EBNA1 complex polypeptide, and methods of using the same. Purified EBNA1 complexes and EBNA1 complex polypeptides are provided, as well as variants of the EBNA1 complexes such as complexes of polypeptide fragments or polypeptide fusions, and chimeric molecules comprised of polypeptide components of the EBNA1 complexes. Also provided are methods of making the EBNA1 complexes and EBNA1 complex polypeptides , methods of detecting, identifying, and purifying the EBNA1 complexes, methods of identifying compounds that modulate the EBNA1 complexes and EBNA1 complex polypeptides, and methods of treating or diagnosing EBV-mediated disorders using the EBNA1 complexes and EBNA1 complex polypeptides and compounds that modulate them.
(FR)La présente invention concerne des complexes composés d'EBNA1 et d'au moins un polypeptide des complexes d'EBNA1, ainsi que des méthodes d'utilisation associées. On utilise des complexes d'EBNA1 purifiés et des polypeptides des complexes d'EBNA1, ainsi que des variantes des complexes d'EBNA1 telles que des complexes de fragments polypeptidiques ou de fusions polypeptidiques, ainsi que des molécules chimères comprenant des composants polypeptidiques des complexes d'EBNA1. Cette invention concerne également des méthodes de préparation de ces complexes d'EBNA1 et des polypeptides des complexes d'EBNA1, des méthodes de détection, d'identification et de purification des complexes d'EBNA1, des méthodes d'identification de composés qui modulent les complexes d'EBNA1 et les polypeptides des complexes d'EBNA1 ainsi que des méthodes de traitement ou de diagnostic de troubles induits par le virus d'Epstein-Barr utilisant les complexes d'EBNA1 et les polypeptides des complexes d'EBNA1 ainsi que des composants qui les modulent.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)