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1. WO2004007478 - DERIVATIVES OF 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Publication Number WO/2004/007478
Publication Date 22.01.2004
International Application No. PCT/EP2003/007021
International Filing Date 02.07.2003
Chapter 2 Demand Filed 03.02.2004
IPC
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • AVENTIS PHARMA DEUTSCHLAND GMBH [DE]/[DE] (AllExceptUS)
  • KLEEMAN, Heinz-Werner [DE]/[DE] (UsOnly)
  • CARRY, Jean-Christophe [FR]/[FR] (UsOnly)
  • DESMAZEAU, Pascal [FR]/[FR] (UsOnly)
  • MIGNANI, Serge [FR]/[FR] (UsOnly)
  • BOUQUEREL, Jean [FR]/[FR] (UsOnly)
  • GENEVOIS-BORELLA, Arielle [FR]/[FR] (UsOnly)
  • RONAN, Baptiste [FR]/[FR] (UsOnly)
Inventors
  • KLEEMAN, Heinz-Werner
  • CARRY, Jean-Christophe
  • DESMAZEAU, Pascal
  • MIGNANI, Serge
  • BOUQUEREL, Jean
  • GENEVOIS-BORELLA, Arielle
  • RONAN, Baptiste
Priority Data
02/0894716.07.2002FR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DERIVATIVES OF 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
(FR) DERIVES DE 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE, PROCEDE DE PREPARATION ET INTERMEDIAIRES UTILISES DANS CE PROCEDE, LEURS UTILISATIONS EN TANT QUE MEDICAMENTS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
Abstract
(EN)
The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-pyrrole derivatives of the formula (I) in which R1 to R3 and Ar have the meanings stated in the claims. The inventive compounds are suitable for example as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arryhthmias and of heart failure.
(FR)
L'invention concerne des dérivés de 3-guanidinocarbonyl-1-hétéroaryl-pyrrole de formule (I) dans laquelle R1 à R3 et Ar représentent les significations données dans les revendications. Les composés de l'invention conviennent en tant que médicaments antiarythmiques avec une composante cardioprotectrice pour la prophylaxie et le traitement d'infarctus ainsi que pour le traitement de l'angine de poitrine. Ils inhibent aussi, d'une manière préventive, les processus physiopathologiques associés au développement de séquelles induites par ischémie, en particulier concernant le déclenchement d'arythmies cardiaques induites par ischémie et l'insuffisance cardiaque.
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