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1. (WO2004007476) GESELLSCHAFT FÜR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007476    International Application No.:    PCT/EP2003/006066
Publication Date: 22.01.2004 International Filing Date: 10.06.2003
IPC:
C07D 277/26 (2006.01), C07D 313/00 (2006.01), C07D 315/00 (2006.01), C07D 327/02 (2006.01), C07D 405/06 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), C07D 493/04 (2006.01), C07D 497/04 (2006.01)
Applicants: GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) [DE/DE]; Mascheroder Weg 1, 38124 Braunschweig (DE) (For All Designated States Except US).
HOEFLE, Gerhard [DE/DE]; (DE) (For US Only)
Inventors: HOEFLE, Gerhard; (DE)
Agent: BOETERS, Hans; Boeters & Lieck, Bereiteranger 15, 81541 München (DE)
Priority Data:
102 32 094.2 15.07.2002 DE
Title (EN) GESELLSCHAFT FÜR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF)
(FR) 5-THIAEPOTHILONES ET EPOTHILONES 15-DISUBSTITUES
Abstract: front page image
(EN)The invention relates to 5-thiapethilones and 15-disubstituted epothilones according to formula I (I) with the following meanings: X= >C = O or >S = O R1 = C1-6 alkyl or C2-6 alkenyl R2 = H or C1-6 alkyl Y - Z = >C=C< or >C-O-C< (epoxide ring) R3 = H, C1-6 alkyl or C2-6 alkenyl R4= bicycloaryl, bicycloheteroaryl or -C(R5) = CH-R6, where R5 = H or CH3 and R6 = aryl or heteroaryl X not being >C=O if R3 = H.
(FR)L'invention concerne des 5-thiaépothilones et des épothilones 15-disubstitués représentés par la formule I (I), répondant aux définitions suivantes: X= >C = O ou >S = O, R1 = alkyle C1-6 ou alcényle C2-6, R2 = H ou alkyle C1-6, Y - Z = >C=C< ou >C-O-C< (noyau époxyde), R3 = H, alkyle C1-6 ou alcényle C2-6, R4= bicycloaryle, bicyclohétéroaryle ou -C(R5) = CH-R6, où R5 = H ou CH3 et R6 = aryle ou hétéroaryle, X n'étant pas >C=O si R3 = H.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)