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1. (WO2004007472) CCR4 ANTAGONIST AND MEDICINAL USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007472    International Application No.:    PCT/JP2003/008654
Publication Date: 22.01.2004 International Filing Date: 08.07.2003
Chapter 2 Demand Filed:    06.01.2004    
IPC:
A61K 31/4965 (2006.01), A61K 31/497 (2006.01), A61K 31/498 (2006.01), A61K 31/506 (2006.01), A61K 31/55 (2006.01), C07D 241/22 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8526 (JP) (For All Designated States Except US).
HABASHITA, Hiromu [JP/JP]; (JP) (For US Only).
KOKUBO, Masaya [JP/JP]; (JP) (For US Only).
SHIBAYAMA, Shiro [JP/JP]; (JP) (For US Only).
TADA, Hideaki [JP/JP]; (JP) (For US Only).
SAGAWA, Kenji [JP/JP]; (JP) (For US Only)
Inventors: HABASHITA, Hiromu; (JP).
KOKUBO, Masaya; (JP).
SHIBAYAMA, Shiro; (JP).
TADA, Hideaki; (JP).
SAGAWA, Kenji; (JP)
Agent: OHIE, Kunihisa; Ohie Patent Office, Horiguchi No.2 Bldg. 7F, 2-6, Nihonbashi-Ningyocho, 2-chome, Chuo-ku, Tokyo 103-0013 (JP)
Priority Data:
2002-200879 10.07.2002 JP
Title (EN) CCR4 ANTAGONIST AND MEDICINAL USE THEREOF
(FR) ANTAGONISTE DU CCR4 ET UTILISATION MEDICINALE CORRESPONDANTE
(JA) CCR4アンタゴニストおよびその医薬用途
Abstract: front page image
(EN)A compound represented by the general formula (I) or a salt thereof; and medicinal uses of these (the symbols in the formula are the same as defined in the description). [I] The compound represented by the general formula (I) has CCR4 antagonistic activity. It is hence useful in the prevention of and/or treatments for diseases in which CCR4 participates, such as inflammation and allergic diseases [e.g., systemic inflammation response syndrome (SIRS), anaphylactic or anaphylactoid reaction, allergic vasculitis, transplant organ rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory eye diseases, inflammatory intestine diseases, cerebral/circulatory diseases, respiratory diseases, skin diseases, and autoimmune diseases].
(FR)L'invention concerne un composé représenté par la formule générale (I) ou un sel de ce dernier ; et des utilisations médicales de ces derniers (les symboles de la formule sont tels que définis dans le descriptif). Le composé représenté par la formule générale (I) possède une activité antagoniste de CCR4. Il est par conséquent utile dans la prévention et/ou les traitements de maladies dans lesquels CCR4 participe, tels que les maladies inflammatoires et allergiques [par exemple le syndrome de réponse inflammatoire systémique (SIRS), la réaction anaphylactique ou anaphylactoïde, les vasculites allergiques, l'hépatite, la néphrite, la néphropathie, la pancréatite, la rhinite, l'arthrite, les maladies optiques inflammatoires, les maladies intestinales inflammatoires, les maladies cérébrales/vasculaires, les maladies respiratoires, les maladies cutanées, et les maladies auto-immunes. ]
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)