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1. (WO2004007471) N-PHENYL-(2R,5S)DIMETHYLPIPERADINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007471    International Application No.:    PCT/JP2003/008860
Publication Date: 22.01.2004 International Filing Date: 11.07.2003
Chapter 2 Demand Filed:    09.10.2003    
IPC:
C07D 213/75 (2006.01), C07D 213/84 (2006.01), C07D 239/42 (2006.01), C07D 295/215 (2006.01)
Applicants: YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 103-8411 (JP) (For All Designated States Except US).
TANIGUCHI, Nobuaki [JP/JP]; (JP) (For US Only).
IMAMURA, Masakazu [JP/JP]; (JP) (For US Only).
HAYAKAWA, Masahiko [JP/JP]; (JP) (For US Only).
KAWAGUCHI, Kenichi [JP/JP]; (JP) (For US Only).
KIMURA, Takenori [JP/JP]; (JP) (For US Only).
KINOYAMA, Isao [JP/JP]; (JP) (For US Only).
KAIZAWA, Hiroyuki [JP/JP]; (JP) (For US Only).
OKADA, Minoru [JP/JP]; (JP) (For US Only).
FURUTANI, Takashi [JP/JP]; (JP) (For US Only)
Inventors: TANIGUCHI, Nobuaki; (JP).
IMAMURA, Masakazu; (JP).
HAYAKAWA, Masahiko; (JP).
KAWAGUCHI, Kenichi; (JP).
KIMURA, Takenori; (JP).
KINOYAMA, Isao; (JP).
KAIZAWA, Hiroyuki; (JP).
OKADA, Minoru; (JP).
FURUTANI, Takashi; (JP)
Agent: NAGAI, Shozo; c/o Yamanouchi Pharmaceutical Co., Ltd., Patent Department, 17-1, Hasune 3-chome, Itabashi-ku, Tokyo 174-8612 (JP)
Priority Data:
2002-203690 12.07.2002 JP
Title (EN) N-PHENYL-(2R,5S)DIMETHYLPIPERADINE DERIVATIVE
(FR) DERIVE DE N-PHENYL-(2R,5S)DIMETHYLPIPERAZINE
(JA) N−フェニル−(2R,5S)ジメチルピペラジン誘導体
Abstract: front page image
(EN)It is intended to provide a novel N-phenyl-(2R,5S)dimethylpiperazine derivative useful as an antiandrogenic drug which is superior to the existing compound in the effect of sufficiently lessening the prostate gland size and has an excellent oral activity. This compound is useful in preventing or treating prostate cancer, prostate gland enlargement, etc. It is also intended to provide a novel intermediate which is useful in producing the above compound.
(FR)L'invention concerne un nouveau dérivé de N-phényl-(2R, 5S)diméthylpipérazine utile comme médicament anti-androgène, supérieur au composé existant en ce qu'il permet de réduire suffisamment la taille de la prostate et possède une excellente activité par voie orale. Ce composé est utile pour prévenir ou traiter le cancer de la prostate, une augmentation du volume de la prostate, etc.. L'invention concerne aussi un nouveau produit intermédiaire utile dans la production du composé décrit.
(JA)本発明は、従来の化合物よりも充分な前立腺縮小効果を示し、かつ経口活性が優れた抗アンドロゲン剤として有用な新規N−フェニル−(2R,5S)ジメチルピペラジン誘導体に関する。本願化合物は、前立腺癌、前立腺肥大症等の予防又は治療に有用である。また、本発明は、本発明化合物の製造に有用な新規な中間体を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)