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1. (WO2004007459) NAPHTHOL, QUINOLINE AND ISOQUINOLINE-DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007459    International Application No.:    PCT/US2003/021518
Publication Date: 22.01.2004 International Filing Date: 10.07.2003
Chapter 2 Demand Filed:    12.02.2004    
IPC:
C07C 275/28 (2006.01), C07C 275/30 (2006.01), C07C 275/32 (2006.01), C07D 213/40 (2006.01), C07D 215/38 (2006.01), C07D 217/02 (2006.01), C07D 217/22 (2006.01), C07D 217/24 (2006.01), C07D 235/14 (2006.01), C07D 307/52 (2006.01), C07D 333/20 (2006.01), C07D 333/58 (2006.01), C07D 401/12 (2006.01), C07D 409/04 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE) (For All Designated States Except US).
CODD, Ellen [US/US]; (US) (For US Only).
DAX, Scott, L. [US/US]; (US) (For US Only).
JETTER, Michele [US/US]; (US) (For US Only).
MCDONNELL, Mark [US/US]; (US) (For US Only).
MCNALLY, James, J. [US/US]; (US) (For US Only).
YOUNGMAN, Mark [US/US]; (US) (For US Only)
Inventors: CODD, Ellen; (US).
DAX, Scott, L.; (US).
JETTER, Michele; (US).
MCDONNELL, Mark; (US).
MCNALLY, James, J.; (US).
YOUNGMAN, Mark; (US)
Agent: JOHNSON, Philip, S.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, NJ 08933 (US)
Priority Data:
60/395,728 12.07.2002 US
60/395,951 15.07.2002 US
Title (EN) NAPHTHOL, QUINOLINE AND ISOQUINOLINE-DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR
(FR) MODULATEURS UREIQUES DU RECEPTEUR VANILLOIDE VR1 DERIVES DU NAPHTOL, DE LA QUINOLINE ET DE L'ISOQUINOLINE
Abstract: front page image
(EN)This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
(FR)La présente invention concerne des ligands du récepteur vanilloïde VR1. L'invention se rapporte en particulier à des urées dérivées du naphtol, de la quinoline et de l'isoquinoline, qui sont de puissants antagonistes ou agonistes du VR1 et qui sont utilisés dans le traitement et la prévention d'états inflammatoires et autres états douloureux chez les mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)