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1. (WO2004007450) NOVEL INDOLINE COMPOUND AND MEDICINAL USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/007450    International Application No.:    PCT/JP2003/009012
Publication Date: 22.01.2004 International Filing Date: 16.07.2003
Chapter 2 Demand Filed:    30.01.2004    
IPC:
A61K 31/404 (2006.01)
Applicants: KYOTO PHARMACEUTICAL INDUSTRIES, LTD. [JP/JP]; 38, Nishinokyo Tsukinowa-cho, Nakakyo-ku, Kyoto-shi, Kyoto 604-8444 (JP) (For All Designated States Except US).
KAMIYA, Shouji [JP/JP]; (JP) (For US Only).
IKAI, Miho [JP/JP]; (JP) (For US Only).
TAKAHASHI, Kenji [JP/JP]; (JP) (For US Only).
TARUMI, Tadatsugu [JP/JP]; (JP) (For US Only).
KASAI, Masayasu [JP/JP]; (JP) (For US Only).
YOSHIMI, Akihisa [JP/JP]; (JP) (For US Only).
SHIRAHASE, Hiroaki [JP/JP]; (JP) (For US Only)
Inventors: KAMIYA, Shouji; (JP).
IKAI, Miho; (JP).
TAKAHASHI, Kenji; (JP).
TARUMI, Tadatsugu; (JP).
KASAI, Masayasu; (JP).
YOSHIMI, Akihisa; (JP).
SHIRAHASE, Hiroaki; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg.,, 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 541-0044 (JP)
Priority Data:
2002-208878 17.07.2002 JP
Title (EN) NOVEL INDOLINE COMPOUND AND MEDICINAL USE THEREOF
(FR) NOUVEAU COMPOSE D'INDOLINE ET SON UTILISATION THERAPEUTIQUE
(JA) 新規インドリン化合物およびその医薬用途
Abstract: front page image
(EN)An indoline compound represented by the general formula (I): (I) (wherein the symbols have the same meanings as in the description) or a pharmaceutically acceptable salt of the compound; and a medicinal composition containing the indoline compound or pharmaceutically acceptable salt. The compound is excellent in ACAT inhibitory activity and lipid peroxidation inhibitory activity and is useful as an ACAT inhibitor or lipid peroxidation inhibitor.
(FR)La présente invention concerne un composé d'indoline représenté par la formule générale (I), dans laquelle les symboles ont les mêmes significations que dans la description, ou un sel pharmaceutiquement acceptable dudit composé. L'invention concerne également une composition thérapeutique contenant le composé d'indoline ou un sel pharmaceutiquement acceptable. Ledit composé présente une activité inhibitrice de l'ACAT et une activité inhibitrice de peroxydation lipidique excellentes et est utile en tant qu'inhibiteur de l'ACAT ou qu'inhibiteur de peroxydation lipidique.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)