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1. (WO2004006941) ANTISENSE COMPOUNDS, METHODS AND COMPOSITIONS FOR TREATING NGAL-RELATED INFLAMMATORY DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/006941    International Application No.:    PCT/SE2003/001217
Publication Date: 22.01.2004 International Filing Date: 15.07.2003
IPC:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Applicants: INDEX PHARMACEUTICALS AB [SE/SE]; Fogdevreten 2A, S-171 77 Stockholm (SE) (For All Designated States Except US).
DIECKMANN, Andreas [DE/SE]; (SE) (For US Only).
LÖFBERG, Robert [SE/SE]; (SE) (For US Only).
VON STEIN, Oliver [GB/SE]; (SE) (For US Only).
VON STEIN, Petra [DE/SE]; (SE) (For US Only).
GOOD, Liam [CA/SE]; (SE) (For US Only)
Inventors: DIECKMANN, Andreas; (SE).
LÖFBERG, Robert; (SE).
VON STEIN, Oliver; (SE).
VON STEIN, Petra; (SE).
GOOD, Liam; (SE)
Agent: HOLMBERG, Martin; Bergenstråhle & Lindvall AB, P.O. Box 17704, S-118 93 Stockholm (SE)
Priority Data:
0202244-0 17.07.2002 SE
60/407,954 05.09.2002 US
Title (EN) ANTISENSE COMPOUNDS, METHODS AND COMPOSITIONS FOR TREATING NGAL-RELATED INFLAMMATORY DISORDERS
(FR) COMPOSES ANTISENS, METHODES ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES
Abstract: front page image
(EN)The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding neutrophil gelatinase associated lipocalin (NGAL). More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding NGAL and thereby inhibiting the expression of the NGAL protein product, as well as pharmaceutical compositions thereof and methods of their use. The antisense oligonucleotide compounds are used for treating diseases such as inflammatory bowel disease, rheumatoid arthritis, psoriasis and asthma.
(FR)la présente invention concerne des composés oligonucléotidiques antisens destinés à moduler l'expression de la fonction de molécules d'acides nucléiques qui codent pour une lipocaline associée à la gélatinase neutrophile (NGAL). Plus particulièrement, l'invention concerne des composés de longueur comprise entre 8 et 50 nucléobases capables de s'hybrider avec des molécules d'acides nucléiques qui codent pour NGAL et, par là même, inhibent l'expression du produit protéique NGAL, ainsi que des compositions pharmaceutiques et leurs méthodes d'utilisation. Les composés oligonucléotidiques antisens s'utilisent pour le traitement de maladies telles que les maladies intestinales inflammatoire, la polyarthrite rhumatoïde, le psoriasis et l'asthme.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)