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1. (WO2004006856) IRON SEQUESTRATION OR ELIMINATION TO REDUCE NEURODEGENERATION OR PARKINSONS DISEASE PROGRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/006856    International Application No.:    PCT/US2003/022112
Publication Date: 22.01.2004 International Filing Date: 11.07.2003
IPC:
A61K 31/47 (2006.01)
Applicants: THE BUCK INSTITUTE FOR RESEARCH ON AGING [US/US]; 8001 Redwood Blvd, Novato, CA 94945 (US) (For All Designated States Except US).
ANDERSEN, Julie, K. [US/US]; (US) (For US Only)
Inventors: ANDERSEN, Julie, K.; (US)
Agent: QUINE, Jonathan, Alan; Quine Intellectual Property Law Group, P.C, P.O. Box 458, Alameda, CA 94501 (US)
Priority Data:
60/395,691 12.07.2002 US
Title (EN) IRON SEQUESTRATION OR ELIMINATION TO REDUCE NEURODEGENERATION OR PARKINSONS DISEASE PROGRESSION
(FR) SEQUESTRATION OU ELIMINATION DU FER POUR REDUIRE LA NEURODEGENERESCENCE OU LA PROGRESSION DE LA MALADIE DE PARKINSON
Abstract: front page image
(EN)This invention pertains to the discovery that elevated level of free iron causal in the onset and/or progression of diseases characterized by neural degeneration (e.g., Parkinson's Disease). It was also discovered that lowering free iron levels can inhibit (e.g. reduce or eliminate) the onset and/or progression of one or more symptoms of such diseases. Thus, in one embodiment this invention provides a method of inhibiting neural degeneration in a mammal. The method involves reducing free iron levels in a neural tissue of said animal in an amount sufficient to inhibit neural degeneration in said neural tissue.
(FR)Selon cette invention, un niveau élevé de fer libre est responsable de l'apparition et/ou de la progression de maladies qui se caractérisent par la dégénérescence neuronale (telles que la maladie de Parkinson). Le fait de réduire les niveaux de fer libre peut inhiber (autrement dit réduire ou éliminer) l'apparition et/ou la progression d'un ou plusieurs symptômes de ces maladies. Ainsi, dans un mode de réalisation, cette invention concerne une méthode permettant d'inhiber la dégénérescence neuronale chez un mammifère. Cette méthode consiste à réduire les niveaux de fer libre dans un tissu neuronal dudit animal d'une quantité suffisante pour que cela entraîne l'inhibition de la dégénérescence neuronale dans ledit tissu neuronal.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)