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1. (WO2004006835) NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/006835    International Application No.:    PCT/US2003/020960
Publication Date: 22.01.2004 International Filing Date: 01.07.2003
IPC:
C07D 307/33 (2006.01), C07D 307/68 (2006.01)
Applicants: FASGEN, LLC. [US/US]; Baview Medical Campus, 5210 Eastern Avenue, Baltimore, MD 21224 (US) (For All Designated States Except US).
THE JOHNS HOPKINS UNIVERSITY [US/US]; 4910 Eastern Avenue, Baltimore, MD 21224 (US) (For All Designated States Except US).
KUHADJA, Francis, P. [US/US]; (US) (For US Only).
MEDGHALCHI, Susan, M. [US/US]; (US) (For US Only).
THUPARI, Jagan, N. [US/US]; (US) (For US Only).
TOWNSEND, Craig, A. [US/US]; (US) (For US Only).
McFADDEN, Jill, M. [US/US]; (US) (For US Only)
Inventors: KUHADJA, Francis, P.; (US).
MEDGHALCHI, Susan, M.; (US).
THUPARI, Jagan, N.; (US).
TOWNSEND, Craig, A.; (US).
McFADDEN, Jill, M.; (US)
Agent: STIEFEL, Maurice, B.; Bryan Cave LLP, 1290 Avenue of the Americas, New York, NY 10167 (US)
Priority Data:
60/392,809 01.07.2002 US
Title (EN) NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
(FR) NOUVEAUX COMPOSES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEURS PROCEDES D'UTILISATION
Abstract: front page image
(EN)Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula (IX): R29 = H, or CI-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, =CHR31, -C(O)OR31, - C(O)R31, -CH2C(O)OR31, CH2C(O)NHR31, where R31 is H or C1-C10 alkyl, cycloalkyl, or alkenyl; R30 = C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X5 = -OR32, or NHR32, Where R32 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R32 group further optionally containing one or more halogen atoms; with the proviso that when R29 is =CH2, then X5 is not OH. Also disclosed are compounds within the scope of the formula (IX), as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.
(FR)L'invention porte sur une composition pharmaceutique comprenant un diluant pharmaceutique et un composé de formule (IX): R29 = H, or CI-C20 alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, =CHR31, -C(O)OR31, - C(O)R31, -CH2C(O)OR31, CH2C(O)NHR31, R31 représentant H ou C1-C10 alkyle, cycloalkyle ou alcényle; R30 = C1-C20 alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle; X5 = -OR32, ou NHR32, R32 représentant H, C1-C20 alkyle, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, le groupe R32 contenant éventuellement un groupe carbonyle, un groupe carboxyle, un groupe carboxyamide, un groupe alcool ou un groupe éther, le groupe R32 contenant également éventuellement un ou plusieurs atomes d'halogène; à condition que lorsque R29 représente =CH2, X5 ne représente pas OH. L'invention porte également sur des composés de formule (IX), ainsi que sur les utilisations des compositions pharmaceutiques dans des applications de perte de charge pondérale, antimicrobiennes et anticancéreuses, dans l'inhibition de la synthase de l'acide gras et du neuropeptide-Y, et dans la stimulation de l'activité de la carnitine palmitoyl transférase-1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)