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1. (WO2004005529) GEF-H1b: BIOMARKERS, COMPLEXES, ASSAYS AND THERAPEUTIC USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005529    International Application No.:    PCT/US2003/020743
Publication Date: 15.01.2004 International Filing Date: 02.07.2003
Chapter 2 Demand Filed:    03.02.2004    
IPC:
C07K 14/47 (2006.01)
Applicants: SUGEN, INC. [US/US]; 230 East Grand Avenue, South San Francisco, CA 94080 (US) (For All Designated States Except US).
SMEAL, Tod, R. [US/US]; (US) (For US Only).
CALLOW, Marinella, G. [AU/US]; (US) (For US Only).
JALLAL, Bahija [MA/US]; (US) (For US Only).
ZOZULYA, Sergey [RU/US]; (US) (For US Only).
GISHIZKY, Mikhail, L. [US/US]; (US) (For US Only)
Inventors: SMEAL, Tod, R.; (US).
CALLOW, Marinella, G.; (US).
JALLAL, Bahija; (US).
ZOZULYA, Sergey; (US).
GISHIZKY, Mikhail, L.; (US)
Agent: BURROUS, Beth, A.; Foley & Lardner, Washington Harbour, 3000 K Street, N.W., Suite 500, Washington, DC 20007-5101 (US)
Priority Data:
60/393,600 05.07.2002 US
60/460,053 04.04.2003 US
Title (EN) GEF-H1b: BIOMARKERS, COMPLEXES, ASSAYS AND THERAPEUTIC USES THEREOF
(FR) GEF-H1B: BIOMARQUEURS, COMPLEXES, ESSAIS ET UTILISATIONS THERAPEUTIQUES CORRESPONDANTES
Abstract: front page image
(EN)The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
(FR)US0320743te invention concerne le diagnostic de la prolifération cellulaire anormale dans des échantillons biologiques et la recherche systématique de médicaments bloquant, atténuant ou annihilant la croissance cellulaire, particulièrement la croissance cellulaire oncogène, par détection d'une isoforme phosphovariante d'un biomarqueur du facteur d'échange nucléotidique de la guanine, et notamment le nouveau GEF-H1S.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)