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1. (WO2004005511) TUMOR-LYSING VIRUS GROWING SELECTIVELY IN TUMOR CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005511    International Application No.:    PCT/JP2003/008573
Publication Date: 15.01.2004 International Filing Date: 07.07.2003
Chapter 2 Demand Filed:    26.12.2003    
IPC:
A61K 35/76 (2006.01), A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/075 (2006.01), C12N 9/12 (2006.01), C12N 15/861 (2006.01)
Applicants: KANSAI TECHNOLOGY LICENSING ORGANIZATION CO., LTD. [JP/JP]; 93, Chudoji Awata-cho, Shimogyo-ku, Kyoto-shi, Kyoto 600-8815 (JP) (For All Designated States Except US).
FUJIWARA, Toshiyoshi [JP/JP]; (JP).
SHIRAKIYA, Yoshiko [JP/JP]; (JP) (For US Only).
KAWASHIMA, Takeshi [JP/JP]; (JP) (For US Only).
TANAKA, Noriaki [JP/JP]; (JP).
KYO, Satoru [JP/JP]; (JP)
Inventors: FUJIWARA, Toshiyoshi; (JP).
SHIRAKIYA, Yoshiko; (JP).
KAWASHIMA, Takeshi; (JP).
TANAKA, Noriaki; (JP).
KYO, Satoru; (JP)
Agent: SAEGUSA, Eiji; Kitahama TNK Building, 1-7-1, Doshomachi, Chuo-ku, Osaka-shi, Osaka 541-0045 (JP)
Priority Data:
2002-198941 08.07.2002 JP
Title (EN) TUMOR-LYSING VIRUS GROWING SELECTIVELY IN TUMOR CELLS
(FR) CROISSANCE SELECTIVE D'UN VIRUS ENTRAINANT UNE LYSE TUMORALE DANS DES CELLULES TUMORALES
(JA) 腫瘍細胞において選択的に増殖する腫瘍融解ウイルス
Abstract: front page image
(EN)By using a telomerase promoter with a virus having a gene sequence containing an E1 gene (preferably E1A gene), an IRES sequence and a sequence containing E1B gene and an anticancer agent with the use of this virus, the virus grows in tumor cells and thus exhibits an efficient anticancer effect.
(FR)L'invention concerne l'utilisation d'un promoteur de la télomérase et d'un virus comprenant une séquence génique contenant un gène E1 (de préférence un gène E1A), une séquence IRES et une séquence contenant un gène E1B et un agent anticancéreux, pour faire croître le virus dans des cellules tumorales et obtenir ainsi un effet anticancéreux sensible.
(JA)テロメラーゼのプロモーターと、E1遺伝子、好ましくはE1A遺伝子、IRES配列及びE1B遺伝子を含む配列とを含む遺伝子配列を有するウイルス及び該ウイルスを用いた抗癌剤を用いることによって、前記ウイルスが腫瘍細胞において増殖することにより、効率の良い抗癌作用を示す。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)