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1. (WO2004005509) METHOD OF EXAMINING ALLERGIC DISAESE AND DRUG FOR TREATING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005509    International Application No.:    PCT/JP2003/008200
Publication Date: 15.01.2004 International Filing Date: 27.06.2003
Chapter 2 Demand Filed:    23.01.2004    
IPC:
A61K 31/5575 (2006.01), A61K 38/00 (2006.01), C07K 14/705 (2006.01)
Applicants: GENOX RESEARCH, INC. [JP/JP]; 5-1-3, Tokodai, Tsukuba-shi, Ibaraki 300-2635 (JP) (For All Designated States Except US).
JAPAN AS REPRESENTED BY GENERAL DIRECTOR OF AGENCY OF NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT [JP/JP]; 10-1, Okura 2-chome, Setagaya-ku, Tokyo 157-8535 (JP) (For All Designated States Except US).
HASHIDA, Ryoichi [JP/JP]; (JP) (For US Only).
KAGAYA, Shinji [JP/JP]; (JP) (For US Only).
SUGITA, Yuji [JP/JP]; (JP) (For US Only).
SAITO, Hirohisa [JP/JP]; (JP) (For US Only)
Inventors: HASHIDA, Ryoichi; (JP).
KAGAYA, Shinji; (JP).
SUGITA, Yuji; (JP).
SAITO, Hirohisa; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 300-0847 (JP)
Priority Data:
2002-193841 02.07.2002 JP
Title (EN) METHOD OF EXAMINING ALLERGIC DISAESE AND DRUG FOR TREATING THE SAME
(FR) METHODE D'EXAMEN D'UNE MALADIE ALLERGIQUE ET MEDICAMENT DESTINE AU TRAITEMENT DE CELLE-CI
(JA) アレルギー性疾患の検査方法、および治療のための薬剤
Abstract: front page image
(EN)Using the differential display method with gene chips, genes showing a different expression level in activated eosinophils of a patient with atopic dermatitis are compared and analyzed. As a result, genes TR3 and TINUR each showing significantly increased expression in activated eosinophils are successfully identified. It is found out that these genes are usable in examining an allergic disease and screening a candidate compound for a remedy therefor.
(FR)L'invention concerne l'utilisation du procédé d'affichage différentiel avec des puces géniques permettant de comparer et d'analyser des gènes présentant un niveau d'expression différent dans des polynucléaires éosinophiles activés d'un patient souffrant de dermatite atopique. Des gènes TR3 et TINUR présentant individuellement une expression largement accrue dans des polynucléaires éosinophiles activés sont ainsi identifiés avec succès. On a découvert que ces gènes peuvent être utilisés dans l'examen d'une maladie allergique et dans le criblage d'un composé candidat pour un remède contre celle-ci.
(JA)アトピー性皮膚炎患者の活性化した好酸球において発現に差の見られる遺伝子を、ジーンチップを用いてディファレンシャルな発現比較解析を行った。その結果、活性化した好酸球において、有意に発現が上昇しているTR3およびTINUR遺伝子を同定することに成功した。本発明者らは、該遺伝子をアレルギー性疾患の検査、および治療薬候補化合物のスクリーニングに使用できることを見出した。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)