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1. (WO2004005457) TFC/ BETA-CATENIN REGULATED GENES FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005457    International Application No.:    PCT/EP2003/007399
Publication Date: 15.01.2004 International Filing Date: 08.07.2003
Chapter 2 Demand Filed:    05.02.2004    
IPC:
A61K 31/00 (2006.01), A61K 39/00 (2006.01), A61K 48/00 (2006.01), C07K 16/30 (2006.01), C12Q 1/68 (2006.01), G01N 33/574 (2006.01)
Applicants: KYLIX B.V. [NL/NL]; Buntlaan 44, NL-3971 JD Driebergen (NL) (For All Designated States Except US).
COLLAND, Frederic [FR/FR]; (FR) (For US Only).
BARKER, Nicholas [GB/NL]; (NL) (For US Only).
CLEVERS, Johannes, Carolus [NL/NL]; (NL) (For US Only).
GOMEZ, Eduard [ES/NL]; (NL) (For US Only).
VAN DE WETERING, Marcus, Lambertus [NL/NL]; (NL) (For US Only).
SUILS, Elena, Sancho [ES/NL]; (NL) (For US Only)
Inventors: COLLAND, Frederic; (FR).
BARKER, Nicholas; (NL).
CLEVERS, Johannes, Carolus; (NL).
GOMEZ, Eduard; (NL).
VAN DE WETERING, Marcus, Lambertus; (NL).
SUILS, Elena, Sancho; (NL)
Agent: HOOIVELD, Arjen, Jan, Winfried; Arnold & Siedsma, Sweelinckplein 1, NL-2517 GK Den Haag (NL).
VERMOUT, Robert; Arnold & Siedsma, Sweelinckplein 1, NL-2517 GK Den Haag (NL)
Priority Data:
02077711.6 08.07.2002 EP
10/197,619 16.07.2002 US
Title (EN) TFC/ BETA-CATENIN REGULATED GENES FOR TREATING CANCER
(FR) UTILISATION DE GENES CIBLES SPECIFIES TCF PERMETTANT D'IDENTIFIER DES MEDICAMENTS POUR LE TRAITEMENT DU CANCER, PLUS PARTICULIEREMENT DU CANCER COLORECTAL, LA SIGNALISATION TCF/$G(B)-CATENINE-WNT JOUANT UN ROLE FONDAMENTAL
Abstract: front page image
(EN)The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/&bgr;-catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/&bgr;-catenin signalling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.
(FR)La présente invention se rapporte à l'utilisation d'inhibiteurs des protéines exprimées du gène cible TCF dont l'expression est régulée par des complexes de TCF/$g(b)-caténine pour la préparation d'une composition thérapeutique en vue du traitement de cancers où la signalisation TCF/$g(b)-caténine est déréglée. De tels inhibiteurs peuvent être des anticorps, de petites molécules, un ARN antisens et un ARNds que l'on utilise dans un ARNi. L'invention se rapporte également à ces inhibiteurs à proprement parlé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)