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1. WO2004005325 - ANTIGEN-POLYMER COMPOSITIONS

Publication Number WO/2004/005325
Publication Date 15.01.2004
International Application No. PCT/US2003/021861
International Filing Date 10.07.2003
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
CPC
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 39/0006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0006Contraceptive vaccins; Vaccines against sex hormones
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants
  • THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • CUI, Chengji (UsOnly)
  • SCHWENDEMAN, Steven, P. [US]/[US] (UsOnly)
  • STEVENS, Vernon, C. [US]/[US] (UsOnly)
Inventors
  • CUI, Chengji
  • SCHWENDEMAN, Steven, P.
  • STEVENS, Vernon, C.
Agents
  • FROST, Kristin, J.
Priority Data
60/394,96710.07.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIGEN-POLYMER COMPOSITIONS
(FR) COMPOSITIONS POLYMERES CONTENANT DES ANTIGENES
Abstract
(EN)
Methods for enhancing immunogenic response to an antigen, particularly a peptide antigen in a mammalian subject. The method comprises administering a biodegrable polymeric delivery system which comprises one or more antigens of interest and a biologically effective amount of one or more basic additives to the mammalian subject. In a highly preferred embodiment, the basic additive in MgCO3, and the biodegradable polymeric delivery system is a PLGA microparticle. The present invention also relates to the immunogenic compositions used in the present method.
(FR)
L'invention concerne des méthodes pour améliorer la réponse à un antigène, notamment à un antigène peptidique chez un sujet mammifère. Ladite méthode consiste à administrer à un sujet mammalien un système de libération polymère biodégradable contenant un ou plusieurs antigènes concernés et une dose efficace au plan biologique d'un ou plusieurs additifs de base. Dans un mode de réalisation idéal, l'additif de base est MgCO3 et le système de libération polymère biodégradable est une microparticule de PLGA. L'invention porte également sur les compositions immunogènes utilisées dans ladite méthode.
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Latest bibliographic data on file with the International Bureau