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1. (WO2004005325) ANTIGEN-POLYMER COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005325    International Application No.:    PCT/US2003/021861
Publication Date: 15.01.2004 International Filing Date: 10.07.2003
IPC:
A61K 39/00 (2006.01), A61K 39/39 (2006.01)
Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION [US/US]; 1960 Kenny Road, Columbus, OH 43210-1063 (US) (For All Designated States Except US).
CUI, Chengji [--/US]; (US) (For US Only).
SCHWENDEMAN, Steven, P. [US/US]; (US) (For US Only).
STEVENS, Vernon, C. [US/US]; (US) (For US Only)
Inventors: CUI, Chengji; (US).
SCHWENDEMAN, Steven, P.; (US).
STEVENS, Vernon, C.; (US)
Agent: FROST, Kristin, J.; Calfee, Halter & Griswold LLP, 800 Superior Avenue, Suite 1400, Cleveland, OH 44114 (US)
Priority Data:
60/394,967 10.07.2002 US
Title (EN) ANTIGEN-POLYMER COMPOSITIONS
(FR) COMPOSITIONS POLYMERES CONTENANT DES ANTIGENES
Abstract: front page image
(EN)Methods for enhancing immunogenic response to an antigen, particularly a peptide antigen in a mammalian subject. The method comprises administering a biodegrable polymeric delivery system which comprises one or more antigens of interest and a biologically effective amount of one or more basic additives to the mammalian subject. In a highly preferred embodiment, the basic additive in MgCO3, and the biodegradable polymeric delivery system is a PLGA microparticle. The present invention also relates to the immunogenic compositions used in the present method.
(FR)L'invention concerne des méthodes pour améliorer la réponse à un antigène, notamment à un antigène peptidique chez un sujet mammifère. Ladite méthode consiste à administrer à un sujet mammalien un système de libération polymère biodégradable contenant un ou plusieurs antigènes concernés et une dose efficace au plan biologique d'un ou plusieurs additifs de base. Dans un mode de réalisation idéal, l'additif de base est MgCO3 et le système de libération polymère biodégradable est une microparticule de PLGA. L'invention porte également sur les compositions immunogènes utilisées dans ladite méthode.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)