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Pub. No.:    WO/2004/005317    International Application No.:    PCT/US2003/020626
Publication Date: 15.01.2004 International Filing Date: 01.07.2003
Chapter 2 Demand Filed:    30.01.2004    
C12N 9/74 (2006.01)
Applicants: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
CARNEY, Darrell, H. [US/US]; (US) (For US Only)
Inventors: CARNEY, Darrell, H.; (US)
Agent: DAVIS, Steven, G.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Road, P.O. Box 9133, Concord, MA 01742-9133 (US)
Priority Data:
60/393,579 02.07.2002 US
Abstract: front page image
(EN)Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
(FR)L'invention porte sur des dimères dérivant de la thrombine comprenant deux polypeptides présentant la séquence d'acide aminé SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, ou un fragment C-terminal tronqué du polypeptide présentant au moins six acides aminés. Zéro, un, deux, ou trois acides aminés du polypeptide, ou du fragment de polypeptide, diffèrent de par leur position correspondante dans SEQ ID NO. 2. L'invention porte également sur des méthodes de traitement de sujets nécessitant un traitement par un agoniste du récepteur de la thrombine consistant à administrer une dose efficace du dérivé de la thrombine décrit ci-dessus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)