Processing

Please wait...

Settings

Settings

Goto Application

1. WO2004005313 - HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES

Publication Number WO/2004/005313
Publication Date 15.01.2004
International Application No. PCT/IB2003/003792
International Filing Date 08.07.2003
Chapter 2 Demand Filed 05.02.2004
IPC
C07J 17/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
17Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopentahydrophenanthrene skeleton
C07J 43/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
Applicants
  • PLIVA - ISTRAZIVACKI INSTITUT d.o.o. [HR]/[HR] (AllExceptUS)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • TOMASKOVIC, Linda [HR]/[HR] (UsOnly)
  • MARKOVIC, Stribor [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, Mladen
  • MESIC, Milan
  • TOMASKOVIC, Linda
  • MARKOVIC, Stribor
Priority Data
60/395,19008.07.2002US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES
(FR) NOUVEAUX COMPOSES, COMPOSITIONS EN TANT QUE PORTEURS POUR MOLECULES ACTIVES ANTI-INFLAMMATOIRES STEROIDIENNES/NON-STEROIDIENNES, ANTINEOPLASIQUES ET ANTIVIRALES
Abstract
(EN) The present invention relates (a) to new compounds represented by Formula I wherein M represents a macrocode subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, V represents and ant-inflammatory steroid or nonsteroid subunit, or an antineoplastic or antiviral subunit and L represents a linking group covalently linking M and V; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory/neoplastic/viral diseases and conditions in humans and animals.
(FR) La présente invention concerne (a) de nouveaux composés représentés par la formule I, dans laquelle M représente une sous-unité de macrolide (groupe caractéristique de macrolide) dérivée d'un macrolide possédant la propriété de s'accumuler dans des cellules inflammatoires, V représente une sous-unité stéroïdienne ou non stéroïdienne inflammatoire ou une sous-unité antinéoplasique ou antivirale et L représente un groupe de liaison liant de manière covalente M et V, ainsi que (b) les sels acceptables au niveau pharmacologique, les promédicaments et les solvates associés, (c) des procédés et des intermédiaires destinés à leur préparation, et (d) leur utilisation dans le traitement de maladies et de troubles inflammatoires, néoplasiques, viraux chez des humains et des animaux.
Related patent documents
YUP-2005/0006This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
HRP20050002AThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
IS7685This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
NO20050575This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
Latest bibliographic data on file with the International Bureau