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1. (WO2004005313) HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES

Pub. No.:    WO/2004/005313    International Application No.:    PCT/IB2003/003792
Publication Date: Fri Jan 16 00:59:59 CET 2004 International Filing Date: Wed Jul 09 01:59:59 CEST 2003
IPC: C07J 17/00
C07J 43/00
Applicants: PLIVA - ISTRAZIVACKI INSTITUT d.o.o.
MERCEP, Mladen
MESIC, Milan
TOMASKOVIC, Linda
MARKOVIC, Stribor
Inventors: MERCEP, Mladen
MESIC, Milan
TOMASKOVIC, Linda
MARKOVIC, Stribor
Title: HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES
Abstract:
The present invention relates (a) to new compounds represented by Formula I wherein M represents a macrocode subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, V represents and ant-inflammatory steroid or nonsteroid subunit, or an antineoplastic or antiviral subunit and L represents a linking group covalently linking M and V; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory/neoplastic/viral diseases and conditions in humans and animals.