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1. WO2004005309 - NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE

Publication Number WO/2004/005309
Publication Date 15.01.2004
International Application No. PCT/HR2003/000035
International Filing Date 07.07.2003
Chapter 2 Demand Filed 06.02.2004
IPC
C07H 17/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
10Laxatives
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
Applicants
  • PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR]/[HR] (AllExceptUS)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • TOMASKOVIC, Linda [HR]/[HR] (UsOnly)
  • MARKOVIC, Stribor [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, Mladen
  • MESIC, Milan
  • TOMASKOVIC, Linda
  • MARKOVIC, Stribor
Common Representative
  • PLIVA - ISTRAZIVACKI INSTITUT D.O.O.
Priority Data
60/394,67108.07.2002US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE
(FR) SUBSTANCES ANTI-INFLAMMATOIRES NON STEROIDIENNES, COMPOSITIONS ET PROCEDES D'UTILISATION DE CELLES-CI
Abstract
(EN) The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a nonsteroidal subunit (nonsteroidal moiety) derived from nonsteroid drug with anti-inflammatory, analgesic and/or antipyretic activity (NSAID) and L represents a linking group covalently linking M and D; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals.
(FR) L'invention concerne (a) des composés représentés par la formule (I). Dans cette formule, M représente une sous-unité macrolide (fraction macrolide) dérivée d'un macrolide possédant la propriété de s'accumuler dans des cellules inflammatoires, D représente une sous-unité non stéroïdienne (fraction non stéroïdienne) dérivée d'un médicament non stéroïdien à activité anti-inflammatoire, analgésique et/ou antipyrétique (NSAID) et L représente un groupe de liaison lié de façon covalente à M et D. Cette invention concerne également (b) des sels, des promédicaments et des solvates de ces composés acceptables sur le plan pharmacologique, (c) des procédés et des intermédiaires destinés à leur préparation, et (d) leur utilisation dans le traitement de maladies et d'affections inflammatoires chez des humains et des animaux.
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