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1. WO2004005285 - NEW QUINUCLIDINE AMIDE DERIVATIVES

Publication Number WO/2004/005285
Publication Date 15.01.2004
International Application No. PCT/EP2003/006708
International Filing Date 25.06.2003
Chapter 2 Demand Filed 02.12.2003
IPC
C07D 453/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
C07D 487/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
08Bridged systems
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
C07D 487/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • ALMIRALL PRODESFARMA AG [CH]/[CH] (AllExceptUS)
  • PRAT QUINONES, Maria [ES]/[ES] (UsOnly)
Inventors
  • PRAT QUINONES, Maria
Agents
  • CRESSWELL, Thomas, Anthony
Priority Data
P 20020153902.07.2002ES
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEW QUINUCLIDINE AMIDE DERIVATIVES
(FR) DERIVES DE QUINUCLIDINE AMIDE
Abstract
(EN)
New quinuclidine amide derivatives having the chemical structure of general formula (I) and pharmaceutically acceptable salts thereof including quaternary salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions 10 comprising them and their use in therapy as antagonists of M3 muscarinic receptors.
(FR)
L'invention concerne de nouveaux dérivés de quinuclidine amide de structure chimique correspondant à la formule générale (I), ainsi que leurs sels pharmaceutiquement compatibles, y compris les sels quaternaires de formule (II). L'invention concerne en outre des procédés de préparation de ces dérivés, des compositions pharmaceutiques les renfermant et leur utilisation en thérapie, comme antagonistes de récepteurs muscariniques M3.
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