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1. (WO2004005283) IMIDAZOLES, OXAZOLES AND THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005283    International Application No.:    PCT/US2003/021524
Publication Date: 15.01.2004 International Filing Date: 09.07.2003
Chapter 2 Demand Filed:    04.02.2004    
IPC:
C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 403/04 (2006.01), C07D 403/14 (2006.01), C07D 405/14 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), C07D 417/04 (2006.01), C07D 417/14 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street, Cambridge, MA 02139-4242 (US) (For All Designated States Except US).
LEDEBOER, Mark [US/US]; (US) (For US Only).
WANG, Jian [CN/US]; (US) (For US Only).
MOON, Young, Choom [KR/US]; (US) (For US Only)
Inventors: LEDEBOER, Mark; (US).
WANG, Jian; (US).
MOON, Young, Choom; (US)
Agent: HALEY, James, F., Jr.; Fish & Neave, 1251 Avenue of the Americas, New York, NY 10020__ (US)
Priority Data:
60/395,202 09.07.2002 US
Title (EN) IMIDAZOLES, OXAZOLES AND THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITIES
(FR) IMIDAZOLES, OXAZOLES ET THIAZOLES PRESENTANT DES ACTIVITES D'INHIBITION DES PROTEINES KINASES
Abstract: front page image
(EN)The present invention provides compounds of formula I: (I) or a pharmaceutically acceptable derivative thereof, wherein R1, R2, A, G, and W are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, Lck, Src, and Aurora kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
(FR)La présente invention concerne des composés représentés par la formule (I) ou un dérivé pharmaceutiquement acceptable de ces derniers; les R1, R2, A, G et W de la formule étant tels que décrits dans le descriptif. Ces composés sont des inhibiteurs des protéines kinases, plus particulièrement de JNK qui est une protéine kinase de mammifère impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse cellulaire aux stimuli extracellulaires, et des kinases Lck, Src et Aurora. Cette invention se rapporte également à des méthodes de production de ces inhibiteurs, à des compositions pharmaceutiques comprenant les inhibiteurs selon l'invention et à des méthodes d'utilisation desdites compositions dans le traitement et la prévention de divers troubles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)