WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004005277) NOVEL COMPUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005277    International Application No.:    PCT/US2003/021700
Publication Date: 15.01.2004 International Filing Date: 09.07.2003
IPC:
C07D 333/32 (2006.01)
Applicants: FASGEN, INC. [US/US]; Bayview Medical Campus, 5210 Eastern Avenue, Baltimore, MD 21224 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
THE JOHNS HOPKINS UNIVERSITY [US/US]; 4910 Eastern Avenue, Baltimore, MD 21224 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
KUHAJDA, Francis, P. [US/US]; (US) (For US Only).
MEDGHALCHI, Susan, M. [US/US]; (US) (For US Only).
MCFADDEN, Jill, M. [US/US]; (US) (For US Only).
THUPARI, Jagan [US/US]; (US) (For US Only).
TOWNSEND, Craig, A. [US/US]; (US) (For US Only)
Inventors: KUHAJDA, Francis, P.; (US).
MEDGHALCHI, Susan, M.; (US).
MCFADDEN, Jill, M.; (US).
THUPARI, Jagan; (US).
TOWNSEND, Craig, A.; (US)
Agent: STIEFEL, Maurice, B.; Bryan Cave LLP, 1290 Avenue of the Americas, New York, NY 10167 (US)
Priority Data:
60/394,585 09.07.2002 US
Title (EN) NOVEL COMPUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
(FR) NOUVEAUX COMPOSÉS, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET MÉTHODES D'UTILISATION DESDITS COMPOSÉS
Abstract: front page image
(EN)A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21= H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH2OR25, -C(O)R25, -CO(O)R25, -C(O)NR25R26, -CH2C(O)R25, or -CH2C(O)NHR25, where R25 and R26 are each independently H, C1-C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22 = -OH, -OR27, -OCH2C(O)R27, -OCH2C(O)NHR27, -OC(O)R27, -OC(O)OR27, -OC(O)NHNH-R5, or -OC(O)NR27R28, where R27 and R28 are each independentlyH, C1 -C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.
(FR)Composition pharmaceutique contenant un diluant pharmaceutique et un composé de formule (IV) dans laquelle R21 représente H, alkyle C1-20, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, -CH2OR25, -C(O)R25, -CO(O)R25, -C(O)NR25R26, -CH2C(O)R25, ou -CH2C(O)NHR25, dans lesquelles R25 et R26 représentent chacun indépendamment H, alkyle C1-10, cycloalkyle, alcényle, aryle, arylalkyle, ou alkylaryle, contenant éventuellement un ou plusieurs atomes d'halogène, R22 représente -OH, -OR27, -OCH2C(O)R27, -OCH2C(O)NHR27, -OC(O)R27, -OC(O)OR27, -OC(O)NHNH-R5, ou -OC(O)NR27R28, dans lesquelles R27 et R28 représentent chacun indépendamment H, alkyle C1-20, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle, R27 et R28 pouvant chacun contenir éventuellement des atomes d'halogène, R23 et R24, qu'ils soient identiques ou différents l'un de l'autre, représentent alkyle C1-20, cycloalkyle, alcényle, aryle, arylalkyle ou alkylaryle. Des méthodes d'utilisation de ces compositions pour traiter le cancer, pour engendrer une perte pondérale, pour traiter des infections microbiennes, pour inhiber le neuropeptide-Y et / ou l'acide gras synthase et pour stimuler CPT-1 sont également décrites.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)