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1. (WO2004005248) PEPTIDE INHIBITORS OF SMAC PROTEIN BINDING TO INHIBITOR OF APOPTOSIS PROTEINS (IAP)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/005248    International Application No.:    PCT/EP2003/007005
Publication Date: 15.01.2004 International Filing Date: 01.07.2003
Chapter 2 Demand Filed:    29.12.2003    
IPC:
C07D 207/08 (2006.01), C07D 207/09 (2006.01), C07D 207/10 (2006.01), C07D 401/12 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GB, GD, GE, GH, GR, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LT, LU, LV, MA, MC, MD, MK, MN, MX, NI, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SE, SG, SI, SK, TJ, TM, TN, TR, TT, UA, UZ, VC, VN, YU, ZA, ZW only).
NOVARTIS PHARMA GMBH [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
SHARMA, Sushil, Kumar [US/US]; (US) (For US Only).
ZAWEL, Leigh [US/US]; (US) (For US Only).
PALERMO, Mark, G. [US/US]; (US) (For US Only).
CHANDRAMOULI, Nagarajan [US/US]; (US) (For US Only).
BAIR, Kenneth, Walter [US/US]; (US) (For US Only)
Inventors: SHARMA, Sushil, Kumar; (US).
ZAWEL, Leigh; (US).
PALERMO, Mark, G.; (US).
CHANDRAMOULI, Nagarajan; (US).
BAIR, Kenneth, Walter; (US)
Agent: GRUBB, Philip; Novartis AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
60/393,150 02.07.2002 US
Title (EN) PEPTIDE INHIBITORS OF SMAC PROTEIN BINDING TO INHIBITOR OF APOPTOSIS PROTEINS (IAP)
(FR) INHIBITEURS PEPTIDIQUES DE LA LIAISON DE LA PROTEINE SMAC AVEC LES PROTEINES INHIBITRICES DE L'APOPTOSE (IAP)
Abstract: front page image
(EN)The present disclosure relates to XIAP inhibitor compounds of the formula I (I) wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
(FR)L'invention concerne des composés inhibiteurs de XIAP représentés par la formule (I), (I). Les substituants sont décrits dans le descriptif. Les composés décrits sont utiles en tant qu'agents thérapeutiques pour le traitement des maladies prolifératives, notamment du cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LT, LU, LV, MA, MD, MK, MN, MX, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SE, SG, SK, TJ, TM, TN, TR, TT, UA, US, UZ, VC, VN, YU, ZA, ZW.
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR).
Publication Language: English (EN)
Filing Language: English (EN)