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Machine translation
1. (WO2004004769) CONJUGATES OF PHOTOSENSITIZERS AND OLIGONUCLEOTIDES FOR SELECTIVE PHOTOCHEMIOTHERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/004769    International Application No.:    PCT/EP2003/008052
Publication Date: 15.01.2004 International Filing Date: 04.07.2003
IPC:
A61K 38/00 (2006.01), A61K 41/00 (2006.01), A61K 47/48 (2006.01), C12N 15/11 (2006.01)
Applicants: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE [CH/CH]; CH-1015 Lausanne (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
VAN DEN BERGH, Hubert [NL/CH]; (CH) (For US Only).
LANGE, Norbert [DE/CH]; (CH) (For US Only)
Inventors: VAN DEN BERGH, Hubert; (CH).
LANGE, Norbert; (CH)
Agent: MANATON, Ross, Timothy; J.Y & G.W. Johnson, Kingsbourne House, 229-231 High Holborn, London WC1V 7DP (GB)
Priority Data:
0215534.9 04.07.2002 GB
Title (EN) CONJUGATES OF PHOTOSENSITIZERS AND OLIGONUCLEOTIDES FOR SELECTIVE PHOTOCHEMIOTHERAPY
(FR) CONJUGUES DE PHOTOSENSIBILISANTS ET D'OLIGONUCLEOTIDES POUR PHOTOCHIMIOTHERAPIE SELECTIVE
Abstract: front page image
(EN)This invention relates to oligonucleotide targeting agents and their use in the treatment of diseased cells by selective photochemotherapy (PCT). PCT is a method of treating human diseases and disorders, bacteriological indications and other pathological conditions. PCT is based on the topical or systemic application of a photosensitizing agent, a precursor or pro-drug thereof, which preferentially accumulates in the target tissue. Irradiation of the photosensitizing agent located in the target. tissue with electromagnetic radiation of an appropriate wavelength and the interaction of the thus excited photosensitive moiety with oxygen leads to tissue damage and destruction of the irradiated areas.
(FR)L'invention concerne des agents de ciblage d'oligonucléotides et leur utilisation dans le traitement de cellules pathologiques par photochimiothérapie sélective (PCT). La PCT est une méthode de traitement de maladies et de troubles, d'indications bactériologiques et d'autres états pathologiques chez l'homme. La PCT comporte l'application topique ou systémique d'un agent photosensibilisant, d'un précurseur ou d'un promédicament de celui-ci, qui s'accumule de préférence dans le tissu cible. L'irradiation, à l'aide d'un rayonnement électromagnétique de longueur d'onde appropriée, de l'agent photosensibilisant qui se situe dans le tissu cible et l'interaction de la fraction photosensible ainsi excitée avec l'oxygène entraîne une lésion du tissu et la destruction des zones irradiées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)