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1. (WO2004004766) MP53S AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/004766    International Application No.:    PCT/US2003/021378
Publication Date: 15.01.2004 International Filing Date: 09.07.2003
IPC:
A61K 31/00 (2006.01), C07K 14/47 (2006.01), C12N 15/11 (2006.01), G01N 33/50 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; P.O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 (US) (For All Designated States Except US).
COSTA, Michael, A. [US/US]; (US) (For US Only).
MAXWELL, Mark, E. [US/US]; (US) (For US Only).
LACKNER, Mark, R. [US/US]; (US) (For US Only).
HUNG, Tak [CN/US]; (US) (For US Only).
O'BRIEN, Carol, L. [US/US]; (US) (For US Only).
JIN, Yisheng [CN/US]; (US) (For US Only).
NICOLL, Monique [US/US]; (US) (For US Only).
HAI, Bing [CN/US]; (US) (For US Only).
ZHANG, HaiGuang [US/US]; (US) (For US Only).
LICKTEIG, Kim [US/US]; (US) (For US Only).
AMUNDSEN, Craig, D. [US/US]; (US) (For US Only)
Inventors: COSTA, Michael, A.; (US).
MAXWELL, Mark, E.; (US).
LACKNER, Mark, R.; (US).
HUNG, Tak; (US).
O'BRIEN, Carol, L.; (US).
JIN, Yisheng; (US).
NICOLL, Monique; (US).
HAI, Bing; (US).
ZHANG, HaiGuang; (US).
LICKTEIG, Kim; (US).
AMUNDSEN, Craig, D.; (US)
Agent: SHAYESTEH, Laleh; Exelixis, Inc., P. O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 (US)
Priority Data:
60/394,992 10.07.2002 US
60/401,604 07.08.2002 US
60/410,988 16.09.2002 US
60/428,837 25.11.2002 US
Title (EN) MP53S AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
(FR) AGENTS MP53 MODIFICATEURS DE LA VOIE METABOLIQUE DE P53 ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)Human MP53 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MP53 are provided.
(FR)L'invention concerne des gènes humains MP53 identifiés en tant que modulateurs de la voie métabolique de p53, et constituant donc des cibles thérapeutiques concernant des troubles associés à une fonction défectueuse de p53. Elle concerne aussi des procédés d'identification de modulateurs de p53, consistant à cribler des agents modulant l'activité de MP53.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)