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1. (WO2004004732) QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/004732    International Application No.:    PCT/GB2003/002874
Publication Date: 15.01.2004 International Filing Date: 04.07.2003
Chapter 2 Demand Filed:    20.01.2004    
IPC:
C07D 405/12 (2006.01), C07D 405/14 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; Sodertalje, S-151 85 (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GB, GD, GE, GH, GM, GR, HR, HU, ID, IE, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, SZ, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1K 1LN (GB) (MG only).
HENNEQUIN, Laurent, Francois, Andre [FR/GB]; (GB) (For US Only).
FOOTE, Kevin, Michael [GB/GB]; (GB) (For US Only).
GIBSON, Keith, Hopkinson [GB/GB]; (GB) (For US Only)
Inventors: HENNEQUIN, Laurent, Francois, Andre; (GB).
FOOTE, Kevin, Michael; (GB).
GIBSON, Keith, Hopkinson; (GB)
Agent: ASTRAZENECA; Global Intellectual Property, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG (GB)
Priority Data:
0215825.1 09.07.2002 GB
0312897.2 05.06.2003 GB
Title (EN) QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
(FR) DERIVES DE QUINAZOLINE UTILISES DANS LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R1, n, R3,Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.
(FR)Cette invention concerne des dérivés de la quinazoline représentés par la formule (I) dans laquelle Z, m, R1, n, R3, Z2 et R14 sont chacun tels que définis dans la description. Cette invention concerne également des procédés de préparation de ces dérivés, des compositions pharmaceutiques les contenant ainsi que leur utilisation dans la préparation d'un médicament utilisé comme agent anti-invasif ou anti-prolifératif pour contenir et/ou traiter une tumeur solide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)