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Pub. No.:    WO/2004/004667    International Application No.:    PCT/US2003/007983
Publication Date: 15.01.2004 International Filing Date: 14.03.2003
A61K 47/48 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US) (For All Designated States Except US).
STEVENSON, Jennifer [US/US]; (US) (For US Only)
Inventors: STEVENSON, Jennifer; (US)
Agent: HAILE, Lisa, A.; Gray Cary Ware & Freidenrich LLP, 4365 Executive Drive, Suite 1100, San Diego, CA 92121-2133 (US)
Priority Data:
60/364,664 15.03.2002 US
Abstract: front page image
(EN)Disclosed are methods and compositions for the treatment of a variety of illnesses by mimicking the outer leaflet of an apoptotic cell to allow for the induction of macrophage phagocytosis to serve as a means of removing unwanted and diseased cells using phosphatidylserine/cell-surface recognition domain conjugate compositions. Also disclosed are methods for making phosphatidylserine/cell-surface recognition domain conjugate compositions and their formulation for use in various pharmaceutical applications including the treatment of diverse cancers and other maladies.
(FR)L'invention concerne des méthodes et des compositions pour le traitement d'une variété de maladies consistant à imiter la valve extérieure d'une cellule apoptotique pour permettre que l'induction d'une phagocytose macrophagique serve de moyen de retrait de cellules non voulues et malades, faisant appel à des compositions de conjugués de domaine de reconnaissance de surface phosphatidylsérine/cellulaire. L'invention concerne des méthodes de fabrication desdites compositions de conjugués de domaine de reconnaissance de surface phosphatidylsérine/cellulaire et leur formulation à utiliser dans des applications pharmaceutiques variées comprenant le traitement de divers cancers et d'autres maladies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)