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1. (WO2004003545) METHODS AND COMPOSITIONS FOR INHIBITION OF MULTI-DRUG RESISTANCE BY HYALURONAN OLIGOMERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/003545    International Application No.:    PCT/US2003/020918
Publication Date: 08.01.2004 International Filing Date: 01.07.2003
Chapter 2 Demand Filed:    14.01.2004    
IPC:
A61K 31/728 (2006.01), A61K 38/13 (2006.01), G01N 33/50 (2006.01)
Applicants: TUFTS UNIVERSITY [US/US]; Ballou Hall, 4th floor, Medford, MA 02155 (US) (For All Designated States Except US).
TOOLE, Bryan, P. [US/US]; (US) (For US Only)
Inventors: TOOLE, Bryan, P.; (US)
Agent: GUTERMAN, Sonia, K.; Lawson & Weitzen, LLP, 88 Black Falcon Ave., Suite 345, Boston, MA 02111 (US)
Priority Data:
60/392,905 01.07.2002 US
60/453,761 11.03.2003 US
Title (EN) METHODS AND COMPOSITIONS FOR INHIBITION OF MULTI-DRUG RESISTANCE BY HYALURONAN OLIGOMERS
(FR) METHODES ET COMPOSITIONS PERMETTANT D'INHIBER LA RESISTANCE PLEIOTROPE AU MOYEN D'OLIGOMERES D'HYALURONANE
Abstract: front page image
(EN)Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, and antibodies specific for hyaluronan receptors.
(FR)La présente invention concerne des compositions pharmaceutiques et des méthodes qui permettent de sensibiliser à des agents chimiothérapeutiques, des cellules cancéreuses qui résistent à plusieurs médicaments ou aux rayonnements. Les compositions comprennent des ligands de récepteurs du hyaluronane, y compris des glycosaminoglycanes tels que des oligomères d'hyaluronane et des dérivés de ces oligomères, des protéines de liaison de l'hyaluronane et des anticorps dirigés spécifiquement contre les récepteurs d'hyaluronane.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)