WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2004003138) NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/003138    International Application No.:    PCT/US2003/019776
Publication Date: 08.01.2004 International Filing Date: 23.06.2003
Chapter 2 Demand Filed:    09.01.2004    
IPC:
A61K 31/70 (2006.01), C07H 19/14 (2006.01), C07H 19/167 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue, Carlsbad, CA 92008 (US) (For All Designated States Except US).
OLSEN, David, B. [US/US]; (US) (For US Only).
MACCOSS, Malcolm [GB/US]; (US) (For US Only).
BHAT, Balkrishen [IN/US]; (US) (For US Only).
ELDRUP, Anne, B. [DK/US]; (US) (For US Only)
Inventors: OLSEN, David, B.; (US).
MACCOSS, Malcolm; (US).
BHAT, Balkrishen; (US).
ELDRUP, Anne, B.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/392,438 27.06.2002 US
Title (EN) NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
(FR) DERIVES NUCLEOSIDIQUES UTILISES COMME INHIBITEURS DE L'ARN POLYMERASE ARN-DEPENDANTE VIRALE
Abstract: front page image
(EN)The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
(FR)La présente invention concerne des composés nucléosidiques et certains de leurs dérivés qui sont des inhibiteurs de l'ARN polymérase ARN-dépendante virale. Ces composés sont des inhibiteurs de la réplication virale de l'ARN ARN-dépendante et sont utiles pour le traitement d'une infection virale ARN ARN-dépendante. Ces composés sont tout particulièrement utiles comme inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), comme inhibiteurs de la réplication du VHC, et/ou pour le traitement d'une infection par le virus de l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant ces composés nucléosidiques seuls ou combinés à d'autres agents actifs contre une infection virale ARN ARN-dépendante, en particulier une infection par le virus de l'hépatite C. L'invention concerne également des méthodes permettant d'inhiber l'ARN polymérase ARN-dépendante, d'inhiber la réplication virale de l'ARN ARN-dépendante, et/ou de traiter une infection virale ARN ARN-dépendante, utilisant les composés nucléosidiques de la présente invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)