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1. (WO2004003015) PEPTIDES HAVING AFFINITY FOR A PHOSPHOLIPID AND USES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/003015    International Application No.:    PCT/FR2003/002025
Publication Date: 08.01.2004 International Filing Date: 30.06.2003
Chapter 2 Demand Filed:    17.01.2004    
IPC:
A61K 38/00 (2006.01), C07K 14/47 (2006.01)
Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE [FR/FR]; 31/33, rue de la Fédération, F-75752 PARIS 15ème (FR) (For All Designated States Except US).
UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) [FR/FR]; 4 Place Jussieu Tour Centrale, F-75252 PARIS CEDEX 05 (FR) (For All Designated States Except US).
SANSON, Alain [FR/FR]; (FR) (For US Only).
OCHSENBEIN, Françoise [FR/FR]; (FR) (For US Only).
DOLLE, Frédéric [FR/FR]; (FR) (For US Only)
Inventors: SANSON, Alain; (FR).
OCHSENBEIN, Françoise; (FR).
DOLLE, Frédéric; (FR)
Agent: AUDIER, Philippe; c/o BREVATOME, 3, rue du Docteur Lancereaux, F-75008 PARIS (FR)
Priority Data:
02 08202 01.07.2002 FR
Title (EN) PEPTIDES HAVING AFFINITY FOR A PHOSPHOLIPID AND USES
(FR) PEPTIDES AYANT UNE AFFINITE POUR UN PHOSPHOLIPIDE ET UTILISATIONS
Abstract: front page image
(EN)The invention concerns a peptide for specific recognition of lipid vectors. The inventive peptide comprises the following peptide sequence (I): J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13-J14-U15-Lys-Gly-X18-Gly-Thr-J21-Glu-J23-J24-U25-J26-J27-J28-U29-J30-J31-Arg-J33-J34-J35-J36-B37-J38-J39-U40-J41-J42-J43-U44-J45-J46-J47-J48-J49-Arg-J51-U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62-J63-J64-Z65-J66-J67-U68-J69-J70-J71-U72-J73-J74-J75 (I), wherein the amino acids J are selected independently of one another among the essential amino acids, or derivatives thereof, such that at least 50 % among them are polar residues selected among Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are selected independently of one another among Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; amino acid X18 is selected independently of the other amino acids of the sequence among Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val; amino acid B37 is selected independently of the other amino acids of the sequence among Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; amino acid Z7 is selected independently of the other amino acids of the sequence among Asp and Gly; the amino acids Z59 and Z65 are selected independently of the other amino acids of the sequence among Glu, Asp, Lys or Arg; the exponents of the residues J, Z, U, X and B represent the position of those amino acids in said sequence.
(FR)La présente invention se rapporte à un peptide pour la reconnaissance spécifique de vecteurs lipidiques. Le peptide de l'invention comprend la séquence peptidique (I) suivante : J¿1?-J¿2?-J¿3?-J¿4?-J¿5?-J¿6?-Z¿7?-U¿8?-J¿9?-J¿10?-U¿11?-Arg-J¿13?-J¿14?-U¿15?-Lys-Gly-X¿18?-Gly-Thr-J¿21?-Glu-J¿23?-J¿24?-U¿25?-J¿26?-J¿27?-J¿28?-U¿29?-J¿30?-J¿3?¿1?-Arg-J¿33?-J¿34?-J¿35?-J¿36?-B¿37?-J¿38?-J¿39?-U¿40?-J¿41?-J¿42?-J¿43?-U¿44?-J¿45?-J¿46?-J¿47?-J¿48?-J¿49?-Arg-J¿51?-U¿52?-J¿53?-J¿54?-Asp-U¿56?-Lys-Ser-Z¿59?-Leu-J¿61?-J¿62?-J¿63?-J¿64?-Z¿65?-J¿66?-J¿67?-U¿68?-J¿69?-J¿70?-J¿71?-U¿72?-J¿73?-J¿74?-J¿75? (I)dans laquelle les acides aminés J sont choisis indépendamment les uns des autres parmi les acides aminés essentiels, ou des dérivés de ceux-ci, de telle manière que au moins 50% d'entre eux sont des résidus polaires choisis parmi Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr et Tyr ; les acides aminés U sont choisis indépendamment les uns des autres parmi Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val ; l'acide aminé X¿18? est choisi indépendamment des autres acides aminés de la séquence parmi Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr et Val ; l'acide aminé B¿37? est choisi indépendamment des autres acides aminés de la séquence parmi Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val ; l'acide aminé Z¿7? est choisi, indépendamment des autres acides aminés de la séquence parmi Asp et Gly ; les acides aminés Z¿59? et Z¿65? sont choisis parmi Glu, Asp, Lys ou Arg ; les exposants des résidus J, Z, U, X et B représentant la position de ces acides aminés dans ladite séquence.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)