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1. (WO2004002477) 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND CORRESPONDING IMINO-HETEROCYCLYL DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/002477    International Application No.:    PCT/EP2003/005898
Publication Date: 08.01.2004 International Filing Date: 05.06.2003
Chapter 2 Demand Filed:    11.12.2003    
IPC:
A61K 31/4155 (2006.01), A61K 31/4178 (2006.01), A61K 31/42 (2006.01), A61K 31/433 (2006.01), C07D 403/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250, 64293 Darmstadt (DE) (For All Designated States Except US).
CEZANNE, Bertram [DE/DE]; (DE) (For US Only).
DORSCH, Dieter [DE/DE]; (DE) (For US Only).
MEDERSKI, Werner [DE/DE]; (DE) (For US Only).
TSAKLAKIDIS, Christos [GR/DE]; (DE) (For US Only).
GLEITZ, Johannes [DE/DE]; (DE) (For US Only).
BARNES, Christopher [GB/DE]; (DE) (For US Only)
Inventors: CEZANNE, Bertram; (DE).
DORSCH, Dieter; (DE).
MEDERSKI, Werner; (DE).
TSAKLAKIDIS, Christos; (DE).
GLEITZ, Johannes; (DE).
BARNES, Christopher; (DE)
Agent: MERCK PATENT GMBH; Frankfurter Strasse 250, 64293 Darmstadt (DE)
Priority Data:
102 29 070.9 28.06.2002 DE
Title (DE) 2-(PHENYL)-2H-PYRAZOL-3-CARBONSÄURE-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMID DERIVATE UND ENTSPRECHENDE IMINO-HETEROCYCLYL DERIVATE SOWIE VERWANDTE VERBINDUNGEN ALS INHIBITOREN DER KOAGULATIONSFAKTOREN XA UND/ODER VIIA ZUR BEHANDLUNG BON THROMBOSEN
(EN) 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND CORRESPONDING IMINO-HETEROCYCLYL DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES
(FR) DERIVES DE 2-(PHENYL)-2H-PYRAZOL-3-ACIDE CARBOXYLIQUE-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMIDE, DERIVES D'IMINO-HETEROCYCLYLE CORRESPONDANTS ET COMPOSES DERIVES SERVANT D'INHIBITEURS DES FACTEURS DE COAGULATION XA ET/OU VIIA DANS LE TRAITEMENT DE THROMBOSES
Abstract: front page image
(DE)Neue Verbindungen der Formel (I) worin D, M, W, X, Y, T, R1 und R1‘ die in Patentanspruch 1 angegebene Bedeutung haben, sind Inhibitoren des Koagulationsfaktors Xa und können zur Prophylaxe und/oder Therapie von thromboembolischen Erkrankungen und zur Behandlung von Tumoren eingesetzt werden.
(EN)The invention relates to the novel compounds of formula (I), wherein D, M, W, X, Y, T, R1 and R1’ are defined as in patent claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
(FR)La présente invention concerne de nouveaux composés de formule (I), dans laquelle D, M, W, X, Y, T, R1 et R1’ ont les significations énoncées dans la revendication 1, qui sont des inhibiteurs du facteur de coagulation Xa et qui peuvent être utilisés pour prévenir et/ou traiter des maladies thromboemboliques et pour traiter des tumeurs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)