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1. WO2004002430 - COMBINATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS

Publication Number WO/2004/002430
Publication Date 08.01.2004
International Application No. PCT/US2003/020737
International Filing Date 30.06.2003
Chapter 2 Demand Filed 11.12.2003
IPC
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
A61K 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
14Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61K 31/135
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
A61K 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
14Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
Applicants
  • COMBINATORX INCORPORATED [US]/[US] (AllExceptUS)
  • JOHANSEN, Lisa, M. [US]/[US] (UsOnly)
  • SERBEDZIJA, George, N. [US]/[US] (UsOnly)
  • AUSPITZ, Benjamin, A. [US]/[US] (UsOnly)
  • ZIMMERMANN, Grant, R. [US]/[US] (UsOnly)
  • KEITH, Curtis [CA]/[US] (UsOnly)
  • NICHOLS, James, M. [US]/[US] (UsOnly)
  • GAW, Debra, A. [US]/[US] (UsOnly)
Inventors
  • JOHANSEN, Lisa, M.
  • SERBEDZIJA, George, N.
  • AUSPITZ, Benjamin, A.
  • ZIMMERMANN, Grant, R.
  • KEITH, Curtis
  • NICHOLS, James, M.
  • GAW, Debra, A.
Agents
  • CLARK, Paul, T.
Priority Data
60/393,03428.06.2002US
60/393,15502.07.2002US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS
(FR) COMBINAISONS POUR LE TRAITEMENT D'INFECTIONS FONGIQUES
Abstract
(EN)
The invention features a method for treating or preventing fungal growth by contacting fungal cells with (I) an aromatic diamidine or analog thereof or a compound formula (I); and (ii) an aminopyridine, a quaternary ammonium compound, or a compound of formula (II) or (III) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit fungal growth.
(FR)
L'invention concerne une méthode de traitement ou de prévention de la prolifération fongique, consistant à mettre en contact des cellules fongiques avec (i) une diamidine aromatique ou analogue ou un composé de formule (I) et (ii) une aminopyridine, un composé d'ammonium quaternaire ou un composé de formule (II) ou (III) simultanément ou dans les 14 jours dans des quantités suffisantes pour réduire ou inhiber la prolifération fongique.
Also published as
Latest bibliographic data on file with the International Bureau