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1. (WO2004002414) SELF-EMULSIFYING FORMULATIONS OF FENOFIBRATE AND/OR FENOFIBRATE DERIVATIVES WITH IMPROVED ORAL BIOAVAILABILITY AND/OR REDUCED FOOD EFFECT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2004/002414    International Application No.:    PCT/US2003/020236
Publication Date: 08.01.2004 International Filing Date: 27.06.2003
Chapter 2 Demand Filed:    26.01.2004    
IPC:
A61K 9/16 (2006.01), A61K 9/20 (2006.01), A61K 9/50 (2006.01)
Applicants: SHIRE LABORATORIES INC. [US/US]; 1150 East Gude Drive, Rockville, MD 20850 (US) (For All Designated States Except US).
LIKAN, Liang [CN/US]; (US) (For US Only).
AMIR, Shojaei, H. [CA/US]; (US) (For US Only).
SCOTT, Ibrahim, A. [US/US]; (US) (For US Only).
BURNSIDE, Beth, A. [US/US]; (US) (For US Only)
Inventors: LIKAN, Liang; (US).
AMIR, Shojaei, H.; (US).
SCOTT, Ibrahim, A.; (US).
BURNSIDE, Beth, A.; (US)
Agent: LAPOINTE, Gregory, P.; Bachman & Lapointe, P.C., 900 Chapel Street, Suite 1201, New Haven, CT 06510-2802 (US)
Priority Data:
60/392,791 28.06.2002 US
10/324,953 20.12.2002 US
Title (EN) SELF-EMULSIFYING FORMULATIONS OF FENOFIBRATE AND/OR FENOFIBRATE DERIVATIVES WITH IMPROVED ORAL BIOAVAILABILITY AND/OR REDUCED FOOD EFFECT
(FR) PREPARATION AUTO EMULSIFIANTES DE FENOFIBRATE ET/OU DE DERIVES DE FENOFIBRATE AVEC LIBERATION DES CARACTERISTIQUES BIOLOGIQUES AMELIOREE ET/OU EFFET ALIMENTAIRE REDUIT
Abstract: front page image
(EN)A fibrate self-emulsifying oral formulation with improved bioavailability when compared to commercially available formulations containing a therapeutically effective dose of fenofibrate, derivative of fenofibrate or mixtures thereof dissolved in a fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone, mono- or di- or polyethylene glycol monoethers, C¿8?-¿12? fatty acid mono- or di-esters of propylene glycol, or combinations thereof, one or more surfactants and optionally one or more stabilizers useful in the treatment of hypercholesterolaemia or hypertriglyceridaemia in mammals in the fed or fasted state.
(FR)La présente invention concerne une préparation orale de fibrate auto émulsifiante avec une libération des caractéristiques biologiques améliorée comparée à des préparations disponibles sur le marché, contenant un dosage efficace de fénofibrate, un dérivé de fénofibrate ou des mélanges de ceux-ci dissous dans un agent de solubilisation de fibrate sélectionné parmi un dérivé N-alkyle de 2-pyrrolidone, mono- ou di- ou polyéthylène glycol monoéthers, C8-12 mono- or di-esters d'acide gras of propylène glycol, ou d'une combinaison de ces composés, un ou plusieurs tensioactifs et éventuellement un ou plusieurs stabilisateurs qui conviennent pour le traitement de l'hypercholestérolémie ou de l'hypertriglycéridémie chez des mammifères nourris ou à jeun.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)