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1. WO2003099827 - 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

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Publication Number WO/2003/099827
Publication Date 04.12.2003
International Application No. PCT/HR2003/000023
International Filing Date 20.05.2003
Chapter 2 Demand Filed 01.12.2003
IPC
C07D 513/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR]/[HR] (AllExceptUS)
  • MERCEP, MLADEN [HR]/[HR] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • MODRIC, Marina [HR]/[HR] (UsOnly)
  • PESIC, Dijana [HR]/[HR] (UsOnly)
  • KIDEMET, Davor [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, MLADEN
  • MESIC, Milan
  • MODRIC, Marina
  • PESIC, Dijana
  • KIDEMET, Davor
Agents
  • PLIVA - ISTRAZIVACKI INSTITUT D.O.O.
  • REDENSEK, Vladimira
Priority Data
P20020451A23.05.2002HR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1-THIA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET PRODUITS INTERMEDIAIRES POUR LEUR PREPARATION
Abstract
(EN) The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-a (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) L'invention se rapporte à des dérivés de la classe des 1-thia-3-aza-dibenzoazulènes, à leurs sels et à leurs solvates pharmacologiquement acceptables, à des procédés et à des produits intermédiaires pour la préparation de ces composés, ainsi qu'à leurs effets anti-inflammatoires, notamment à l'inhibition de la production du facteur $g(a) de nécrose tumorale (TNF-$g(a)) et à l'inhibition de la production d'interleukine-1 (IL-1), ainsi qu'à leur action analgésique.
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