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1. (WO2003099827) 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/099827 International Application No.: PCT/HR2003/000023
Publication Date: 04.12.2003 International Filing Date: 20.05.2003
Chapter 2 Demand Filed: 01.12.2003
IPC:
C07D 513/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, MLADEN [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
MODRIC, Marina [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
KIDEMET, Davor [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, MLADEN; HR
MESIC, Milan; HR
MODRIC, Marina; HR
PESIC, Dijana; HR
KIDEMET, Davor; HR
Agent:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
REDENSEK, Vladimira; Patenta Pisarna, D.O.O. Copova 14 P.O.B. 1725 1001 Ljubliana, SI
Priority Data:
P20020451A23.05.2002HR
Title (EN) 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1-THIA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET PRODUITS INTERMEDIAIRES POUR LEUR PREPARATION
Abstract:
(EN) The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-a (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) L'invention se rapporte à des dérivés de la classe des 1-thia-3-aza-dibenzoazulènes, à leurs sels et à leurs solvates pharmacologiquement acceptables, à des procédés et à des produits intermédiaires pour la préparation de ces composés, ainsi qu'à leurs effets anti-inflammatoires, notamment à l'inhibition de la production du facteur $g(a) de nécrose tumorale (TNF-$g(a)) et à l'inhibition de la production d'interleukine-1 (IL-1), ainsi qu'à leur action analgésique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)