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1. (WO2003099823) 1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/099823 International Application No.: PCT/HR2003/000025
Publication Date: 04.12.2003 International Filing Date: 20.05.2003
Chapter 2 Demand Filed: 01.12.2003
IPC:
C07D 491/04 (2006.01) ,C07D 495/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC,Milan [HR/HR]; HR (UsOnly)
RUPCIC, Renata [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC,Milan; HR
RUPCIC, Renata; HR
PESIC, Dijana; HR
Agent:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; Attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
ROS, Zlata; C/o Patentna Pisarna D.O.O. Copova 14 POB 1725 1001 Ljubljana, SI
Priority Data:
P20020453A23.05.2002HR
Title (EN) 1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1,3-DIAZA-DIBENZOAZULENES EN TANT QU'INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE TUMORALE ET INTERMEDIAIRES DESTINES A LA PREPARATION DE CEUX-CI
Abstract:
(EN) The present invention relates to 1,3-diaza-dibenzoazulene derivatives of formula (I), to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-&agr; (TNF-&agr;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) L'invention concerne des dérivés de classe de 1-thia-3-aza-dibenzoazulène représentés par la formule (I). L'invention concerne également des sels et des solvates de ces dérivés acceptables sur le plan pharmacologique, des procédés et des intermédiaires destinés à la préparation de ces dérivés ainsi que leurs effets anti-inflammatoires, notamment l'inhibition de production du facteur de nécrose tumorale $g(a) (TNF-$g(a)) et l'inhibition de production d'interleukine-1 (IL-1), ainsi que leur action analgésique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)