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1. (WO2003099822) 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/099822 International Application No.: PCT/HR2003/000022
Publication Date: 04.12.2003 International Filing Date: 20.05.2003
Chapter 2 Demand Filed: 01.12.2003
IPC:
C07D 491/04 (2006.01) ,C07D 495/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC, Milan; HR
PESIC, Dijana; HR
Agent:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; Attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
ROS, Zlata; C/o Patentna Pisarna D.O.O. Copova 14 POB 1725 1001 Ljubljana, SI
Priority Data:
P20020452A23.05.2002HR
Title (EN) 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1,2-DIAZA-DIBENZOAZULENES UTILISES EN TANT QU'INHIBITEURS DE LA PRODUCTION DE FACTEUR DE NECROSE DES TUMEURS ET INTERMEDIAIRES PERMETTANT LA PREPARATION DE CES COMPOSES
Abstract:
(EN) The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-(x (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) L'invention concerne des dérivés de 1,2-diaza-dibenzoazulène, let es sels et les solvates pharmacologiquement acceptables de ceux-ci, des procédés et des intermédiaires permettant préparer ces dérivés, ainsi que leurs actions anti-inflammatoires, en particulier l'inhibition de la production de facteur de nécrose des tumeurs $g(a) (TNF-$g(a)) et l'inhibition de la production d'interleukine-1 (IL-1) ainsi que leur action analgésique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)