WO2003099822 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Publication Number WO/2003/099822

Publication Date 04.12.2003

International Application No. PCT/HR2003/000022

International Filing Date 20.05.2003

Chapter 2 Demand Filed 01.12.2003

IPC

CPC

View more classifications

View less classifications

Applicants

PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR]/[HR] (AllExceptUS)
MERCEP, Mladen [HR]/[HR] (UsOnly)
MESIC, Milan [HR]/[HR] (UsOnly)
PESIC, Dijana [HR]/[HR] (UsOnly)

Inventors

MERCEP, Mladen
MESIC, Milan
PESIC, Dijana

Agents

PLIVA - ISTRAZIVACKI INSTITUT D.O.O.
ROS, Zlata

Priority Data

P20020452A

23.05.2002

Publication Language English (en)

Filing Language English (EN)

Designated States

View all

Title

(EN) 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

(FR) 1,2-DIAZA-DIBENZOAZULENES UTILISES EN TANT QU'INHIBITEURS DE LA PRODUCTION DE FACTEUR DE NECROSE DES TUMEURS ET INTERMEDIAIRES PERMETTANT LA PREPARATION DE CES COMPOSES

Abstract

(EN) The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-(x (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

(FR) L'invention concerne des dérivés de 1,2-diaza-dibenzoazulène, let es sels et les solvates pharmacologiquement acceptables de ceux-ci, des procédés et des intermédiaires permettant préparer ces dérivés, ainsi que leurs actions anti-inflammatoires, en particulier l'inhibition de la production de facteur de nécrose des tumeurs $g(a) (TNF-$g(a)) et l'inhibition de la production d'interleukine-1 (IL-1) ainsi que leur action analgésique.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
495	Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
495	Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
04	for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. WO2003099822 - 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF