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1. (WO2003097649) 1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/097649 International Application No.: PCT/HR2003/000024
Publication Date: 27.11.2003 International Filing Date: 20.05.2003
Chapter 2 Demand Filed: 01.12.2003
IPC:
C07D 493/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC, Milan; HR
PESIC, Dijana; HR
Agent:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; Attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
REDENSEK, Vladimira; Patenta Pisarna, D.O.O. Copova 14 P.O.B. 1725 1001 Ljubliana, SI
Priority Data:
P20020441A21.05.2002HR
Title (EN) 1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1-OXA-DIBENZOAZULENES COMME INHIBITEURS DE LA PRODUCTION DU FACTEUR DE NECROSE DES TUMEURS ET INTERMEDIAIRES POUR LEUR PREPARATION
Abstract:
(EN) The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-cc (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) L'invention concerne des dérivés de 1-oxa-dibenzoazulène, les solvates et les sels pharmacologiquement acceptables de ces dérivés, des procédés et des intermédiaires pour la préparation de ces dérivés ainsi que les effets anti-inflammatoires qu'ils exercent, en particulier pour inhiber la production du facteur $g(a) de nécrose des tumeurs (TNF-$g(a)) et celle de l'interleukine 1 (IL-1), de même que l'action analgésique de ces dérivés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)