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1. (WO2003090599) METHODS AND APPARATUS FOR MODIFYING PROPERTIES OF THE BBB AND CEREBRAL CIRCULATION BY USING THE NEUROEXCITATORY AND/OR NEUROINHIBITORY EFFECTS OF ODORANTS ON NERVES IN THE HEAD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2003/090599 International Application No.: PCT/IL2003/000338
Publication Date: 06.11.2003 International Filing Date: 25.04.2003
Chapter 2 Demand Filed: 25.11.2003
IPC:
A61B 17/00 (2006.01) ,A61B 19/00 (2006.01) ,A61K 9/12 (2006.01) ,A61K 45/00 (2006.01) ,A61M 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
17
Surgical instruments, devices or methods, e.g. tourniquets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
19
Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B1/-A61B18/149
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
12
Aerosols; Foams
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
31
Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Applicants:
BRAINSGATE LTD. [IL/IL]; Beit HaTamar 17 HaTidhar Street P.O. Box 2249 43654 Ra'anana, IL (AllExceptUS)
SHALEV, Alon [IL/IL]; IL (UsOnly)
Inventors:
SHALEV, Alon; IL
Agent:
SANFORD T. COLB & CO. ; P.O. Box 2273 76122 Rehovot, IL
LUDWIG, Peter, S. ; Darby & Darby P.C. 805 Third Avenue New York, NY 10022, US
Priority Data:
60/376,04825.04.2002US
60/461,23208.04.2003US
Title (EN) METHODS AND APPARATUS FOR MODIFYING PROPERTIES OF THE BBB AND CEREBRAL CIRCULATION BY USING THE NEUROEXCITATORY AND/OR NEUROINHIBITORY EFFECTS OF ODORANTS ON NERVES IN THE HEAD
(FR) METHODES ET APPAREIL PERMETTANT DE MODIFIER LES PROPRIETES DE LA BARRIERE HEMATO-ENCEPHALIQUE ET DE LA CIRCULATION CEREBRALE A L'AIDE D'EFFETS NEUROEXCITATEURS ET/OU NEUROINHIBITEURS D'AGENTS ODORANTS SUR LES NERFS DE LA TETE
Abstract:
(EN) A method for modifying a property of a brain of a patient includespresenting an odorant to an air passage of the patient, the odorant havingbeen selected for presentation to the air passage because it is such as toincrease conductance of molecules from a systemic blood circulation of thepatient through a blood brain barrier (BBB) of the brain into brain tissueof the patient. The molecules are selected from the group consisting of: apharmacological agent, a therapeutic agent, an endogenous agent, and anagent for facilitating a diagnostic procedure.
(FR) L'invention concerne une méthode permettant de modifier une propriété cérébrale d'un patient qui consiste à présenter un agent odorant dans un passage aérien dudit patient, ledit agent odorant ayant été sélectionné pour être présenté dans le passage aérien afin d'augmenter la conductance de molécules de la circulation sanguine systémique du patient à travers la barrière hémato-encéphalique (BBB) du cerveau dans le tissu cérébral de ce patient. Les molécules sont sélectionnées dans le groupe constitué par un agent apharmacologique, un agent thérapeutique, un agent endogène et un anagent afin de faciliter une procédure de diagnostic.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ536393KR1020050000409EP1503734JP2006500318US20050266099US20050159790
CA2483635AU2003223087