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1. (WO2003087392) MODULATION OF STEM AND PROGENITOR CELL DIFFERENTIATION, ASSAYS, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/087392 International Application No.: PCT/US2003/011327
Publication Date: 23.10.2003 International Filing Date: 13.04.2003
Chapter 2 Demand Filed: 10.11.2003
IPC:
C12N 5/0784 (2010.01) ,C12N 5/0789 (2010.01) ,A61K 35/12 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0784
Dendritic cells; Progenitors thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0789
Stem cells; Multipotent progenitor cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
Applicants:
HARIRI, Robert, J. [US/US]; US (UsOnly)
STIRLING, David, I. [GB/US]; US (UsOnly)
CHAN, Kyle, W., H. [US/US]; US (UsOnly)
MOUTOUH-DE PARSEVAL, Laure, A. [FR/US]; US (UsOnly)
CELGENE CORPORATION [US/US]; 7 Powder Horn Drive Warren, NJ 07059, US (AllExceptUS)
Inventors:
HARIRI, Robert, J.; US
STIRLING, David, I.; US
CHAN, Kyle, W., H.; US
MOUTOUH-DE PARSEVAL, Laure, A.; US
Agent:
INSOGNA, Anthony, M.; Pennie & Edmonds LLP 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
60/372,34812.04.2002US
60/437,34831.12.2002US
60/437,35031.12.2002US
Title (EN) MODULATION OF STEM AND PROGENITOR CELL DIFFERENTIATION, ASSAYS, AND USES THEREOF
(FR) MODULATION DE LA DIFFERENCIATION DE CELLULES SOUCHES ET PROGENITRICES, ANALYSES ET UTILISATIONS CORRESPONDANTES
Abstract:
(EN) The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
(FR) La présente invention se rapporte à des procédés de modulation de la différenciation de cellules souches et de cellules progénitrices de mammifère. Ces procédés peuvent être mis en oeuvre pour réguler et surveiller la différenciation et la maturation de cellules souches mammaliennes, en particulier humaines, ainsi que de lignées cellulaires et tissulaires spécifiques. Les procédés de la présente invention font appel à certaines petites molécules organiques pour moduler la différenciation de populations de cellules souches ou progénitrices ainsi que de lignées cellulaires et tissulaires spécifiques, et en particulier la différenciation de cellules souches de type embryonnaire provenant d'un placenta de post-partum ou la différenciation de cellules progénitrices précoces en une lignée granulocytique. L'invention se rapporte finalement à l'utilisation de telles cellules souches ou progénitrices différenciées à des fins de transplantation et d'autres traitements médicaux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)