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1. (WO2003084964) 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/084964 International Application No.: PCT/HR2003/000015
Publication Date: 16.10.2003 International Filing Date: 09.04.2003
Chapter 2 Demand Filed: 30.10.2003
IPC:
C07D 263/52 (2006.01) ,C07D 498/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
BENKO, Iva [HR/HR]; HR (UsOnly)
PLIVA - ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC, Milan; HR
PESIC, Dijana; HR
BENKO, Iva; HR
Agent:
PATENTNA PISARNA D.O.O.; Copova 14 POB 1725 1001 Ljubljana, SI
Common
Representative:
PLIVA - ISTRAZIVACKI INSTITUT D.O.O.; Attn. Kresimir Sarcevic Prilaz baruna Filipovica 29 HR-10000 Zagreb, HR
Priority Data:
P020304A10.04.2002HR
Title (EN) 1-OXA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PRODUCTION THEREOF
(FR) 1-OXA-3-AZA-DIBENZOAZULENES UTILISES COMME INHIBITEURS DE LA PRODUCTION DU FACTEUR DE NECROSE TUMORALE, ET INTERMEDIAIRES DESTINES A LA PRODUCTION DE CES DERNIERS
Abstract:
(EN) The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-&agr; (TNF-&agr;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR) La présente invention se rapporte à des dérivés de la classe des 1-oxa-3-aza-dibenzoazulènes, à leurs sels et solvates pharmaceutiquement acceptables, à des procédés et intermédiaires de préparation de ces derniers, à leurs effets anti-inflammatoires, en particulier à l'inhibition de la production du facteur de nécrose tumorale $g(a) (TNF-$g(a)) et à l'inhibition de la production d'interleukine 1 (IL-1), et à leurs effets analgésiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)