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1. (WO2003084962) 2-THIA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/084962    International Application No.:    PCT/HR2003/000016
Publication Date: 16.10.2003 International Filing Date: 09.04.2003
Chapter 2 Demand Filed:    30.10.2003    
IPC:
C07D 333/80 (2006.01), C07D 495/04 (2006.01)
Applicants: PLIVA-ISTRAZIVACKI INSTITUT D.O.O. [HR/HR]; Prilaz baruna Filipovica 29, 10000 Zagreb (HR) (For All Designated States Except US).
MERCEP, Mladen [HR/HR]; (HR) (For US Only).
MESIC, Milan [HR/HR]; (HR) (For US Only).
PESIC, Dijana [HR/HR]; (HR) (For US Only).
OZIMEC, Ivana [HR/HR]; (HR) (For US Only)
Inventors: MERCEP, Mladen; (HR).
MESIC, Milan; (HR).
PESIC, Dijana; (HR).
OZIMEC, Ivana; (HR)
Priority Data:
P020305A 10.04.2002 HR
Title (EN) 2-THIA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 2-THIA-DIBENZOAZULENES COMME INHIBITEURS DE LA PRODUCTION DU FACTEUR ONCONECROSANT ET INTERMEDIAIRES DE PREPARATION CORRESPONDANTS
Abstract: front page image
(EN)The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-&agr; (TNF-&agr;) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR)L'invention concerne des composés de la classe de 2-thia-dibenzoazulène, les solvates et sels pharmacologiquement acceptables de ces composés, les procédés et les intermédiaires de préparation de ces composés ainsi que leurs effets anti-inflammatoires. L'invention concerne particulièrement l'inhibition de la production du facteur onconécrosant ? (TNF-?) et l'inhibition de la production de l'interleukine 1 (IL-1), ainsi que l'action analgésique des composés précités.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)